Sentinel lymph node biopsy in breast cancer--experience with the combined use of dye and radioactive tracer at Aarhus University Hospital
| Autor: | Jens Peter Garne, Peer Christiansen, Anders Lernevall, Flemming Brandt Sørensen, Flemming Melsen, Mette Cathrine Lauridsen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Patent Blue V
Cohort Studies chemistry.chemical_compound Frozen Sections Coloring Agents Ultrasonography Aged 80 and over medicine.diagnostic_test Micrometastasis Hematology General Medicine Middle Aged Prognosis Immunohistochemistry medicine.anatomical_structure Oncology Lymphatic Metastasis Female Radiology Adult medicine.medical_specialty Axillary lymph nodes Sentinel lymph node Breast Neoplasms Risk Assessment Sensitivity and Specificity Breast cancer Predictive Value of Tests Biopsy Preoperative Care medicine Humans Radiology Nuclear Medicine and imaging Neoplasm Invasiveness Radionuclide Imaging Aged Neoplasm Staging Retrospective Studies Radioisotopes Intraoperative Care business.industry Sentinel Lymph Node Biopsy Axillary Lymph Node Dissection medicine.disease Surgery Axilla chemistry Lymph Nodes business |
| Zdroj: | Lauridsen, M C, Garne, J P, Sørensen, F B, Melsen, F, Lernevall, A & Christiansen, P 2004, ' Sentinel lymph node biopsy in breast cancer--experience with the combined use of dye and radioactive tracer at Aarhus University Hospital. ' Acta Oncologica, vol. 43, no. 1, pp. 20-6 . Lauridsen, M C, Garne, J P, Sørensen, F B, Melsen, F, Lernevall, A & Christiansen, P 2004, ' Sentinel lymph node biopsy in breast cancer--experience with the combined use of dye and radioactive tracer at Aarhus University Hospital ', Acta Oncologica, bind 43, nr. 1, s. 20-26 . Aarhus University |
| Popis: | One hundred and twenty-four patients with palpable tumours underwent sentinel lymph node biopsy (SLNB) and subsequent axillary lymph node dissection. Ultrasound of the axilla was used as part of the diagnostic work-up on all patients and those with lymph node metastasis verified by fine-needle aspiration biopsy (FNAB) were not included. For identifying the SLNs, a combination of Tc-99m-labelled human albumin (Solco-ALBU-RES) and blue dye (Patent Blue V) was used. No lymphoscintigraphy was performed. The SLN was successfully identified in 122 out of 124 (98%) patients and 66 (54%) patients were found to have metastatic involvement of the axillary lymph nodes. In 52 (79%) of these patients, the SLNs were the only nodes involved, 28 (54%) had micrometastasis only. The false-negative rate was 1.5%. This method has proven valid in the staging of the axilla in patients with breast cancer. The advanced techniques of serial sectioning and immunohistochemical staining further improve the diagnostic advantage offered by the SLNB, as it increases the possibility of diagnosing micrometastatic deposits. Udgivelsesdato: 2004-null |
| Databáze: | OpenAIRE |
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