Social Disadvantage: Cause or Consequence of Impending Psychosis?
| Autor: | Robin M. Murray, Anna Kolliakou, Anthony S. David, Simona A. Stilo, Carmine M. Pariante, Miriam Sirianni, Paola Dazzan, Manuela Russo, Craig Morgan, Heather Taylor, Tiago Reis Marques, Marta Di Forti, Rocco Antonio Zoccali, Alessandra Paparelli, Emma Claire Palmer, Valeria Mondelli, Jennifer O'Connor, Rowena Handley, Aurora Falcone |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Risk separation Psychosis medicine.medical_specialty Time Factors Adolescent social disadvantage Odds 17 Psychology And Cognitive Sciences Life Change Events Young Adult 03 medical and health sciences 0302 clinical medicine Anxiety Separation London medicine Humans Parental Death Young adult Psychiatry Disadvantage Aged First episode unemploy ment Confounding Case-control study loss Regular Article 11 Medical And Health Sciences Middle Aged medicine.disease 3. Good health 030227 psychiatry schizophrenia Psychiatry and Mental health Psychotic Disorders Socioeconomic Factors Unemployment Schizophrenia Case-Control Studies Female unemployment environment Psychology 030217 neurology & neurosurgery |
| Zdroj: | Schizophrenia Bulletin |
| ISSN: | 1745-1701 0586-7614 |
| DOI: | 10.1093/schbul/sbs112 |
| Popis: | BACKGROUND: An association between social disadvantage and established psychosis is well documented in the literature, but there remains a lack of data on the social circumstances of patients before they became ill. We investigated whether social disadvantage at, and prior to, first contact with psychiatric services, is associated with psychosis. METHOD: We collected information on social disadvantage in childhood and adulthood from 278 cases presenting with their first episode of psychosis to the South London and Maudsley National Health Service Foundation Trust and from 226 controls recruited from the local population. Three markers of childhood social disadvantage and 3 markers of disadvantage in adulthood were analyzed. RESULTS: Long term separation from, and death of, a parent before the age of 17 years were both strongly associated with a 2- to 3-fold-increased odds of psychosis. Cases were also significantly more likely to report 2 or more markers of adult social disadvantage than healthy controls (OR = 9.03) at the time of the first presentation with psychosis, independent of a number of confounders. When we repeated these analyses for long-standing adult social disadvantage, we found that the strength of the association decreased but still remained significant for 1 year (OR = 5.67) and 5 years (OR = 2.57) prior to the first contact. CONCLUSIONS: Social disadvantage indexes exposure to factors operating prior to onset that increase the risk of psychosis, both during childhood and adulthood. |
| Databáze: | OpenAIRE |
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