Drug-induced Hemolysis in G6PD Deficiency: an Unusual Presentation of a Common Clinical Condition
| Autor: | Mahabala Chakrapani, Ashok K Shenoy, Ashwin Kamath, Anudeep Padakanti |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Drug Male medicine.medical_specialty media_common.quotation_subject lcsh:Medicine Isosorbide Dinitrate Gastroenterology Hemolysis intravascular hemolysis 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans 030212 general & internal medicine media_common business.industry lcsh:R Cardiovascular Agents General Medicine Hydralazine Middle Aged medicine.disease Discontinuation Intravascular hemolysis Drug Combinations 030104 developmental biology Glucosephosphate Dehydrogenase Deficiency Heart failure g6pd deficiency Isosorbide dinitrate Presentation (obstetrics) business medicine.drug |
| Zdroj: | Acta Medica, Vol 62, Iss 4, Pp 166-169 (2020) |
| ISSN: | 1805-9694 |
| Popis: | Glucose-6-phosphate dehydrogenase (G6PD) deficiency can present a diagnostic dilemma owing to the varying degrees of disease severity and the wide range of precipitating factors. Here, we report a case of a 56-year-old man who presented with signs and symptoms of heart failure and, during the course of treatment, developed intravascular hemolysis. On investigation, he was found to be G6PD deficient. Following discontinuation of the fixed-dose combination of isosorbide dinitrate and hydralazine, the clinical condition of the patient improved, and there were no further episodes of hemolysis. The case highlights the need for a high degree of suspicion of G6PD deficiency in patients with unexplained signs and symptoms of intravascular hemolysis. |
| Databáze: | OpenAIRE |
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