Preoperative statin therapy and infectious complications in cardiac surgery
| Autor: | Hartholt, N L, Rettig, T C D, Schijffelen, M, Morshuis, W J, van de Garde, E M W, Noordzij, P G, Sub Pharmacotherapy, Theoretical, Pharmacoepidemiology and Clinical Pharmacology |
|---|---|
| Přispěvatelé: | Sub Pharmacotherapy, Theoretical, Pharmacoepidemiology and Clinical Pharmacology |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Statin medicine.drug_class business.industry Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] Antibiotics Statins Odds ratio Statin treatment Cardiac surgery Surgery Postoperative infection medicine Original Article In patient Statin therapy Cardiology and Cardiovascular Medicine business GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Surgical site infection |
| Zdroj: | Netherlands Heart Journal, 22, 503-9 Netherlands Heart Journal, 22(11), 503. Bohn Stafleu van Loghum Netherlands Heart Journal, 22, 11, pp. 503-9 Netherlands Heart Journal |
| ISSN: | 1568-5888 |
| Popis: | AIM: To assess whether preoperative statin therapy is associated with the risk of postoperative infection in patients undergoing cardiac surgery. METHODS: 520 patients undergoing cardiac surgery in 2010 were retrospectively examined. Data regarding statin and antibiotic use prior to and after surgery were available from the hospital pharmacy information system. Cultures and clinical data of patients on postoperative antibiotics other than standard prophylactic therapy were studied to identify postoperative infections up to 30 days from day of surgery. RESULTS: 370 (71.2 %) patients were on preoperative statin therapy. Overall, 82 patients (15.8 %) suffered from postoperative infection of which 11 were surgical site infections. In multivariable regression analysis, statin therapy was associated with a reduced risk of postoperative infection (adjusted odds ratio: 0.329, 95 %: CI 0.19-0.57; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink