Application of a dual mechanistic approach to support bilastine dose selection for older adults
Autor: | Stephan Schmidt, Cristina Campo, Nerea Leal, Aintzane García-Bea, Valvanera Vozmediano, Valentina Lo Re, John C. Lukas, Chaejin Kim, Elena Suarez, Monica Rodriguez |
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Rok vydání: | 2021 |
Předmět: |
Adult
Male Senescence PK Physiologically based pharmacokinetic modelling talinolol Adolescent Population Administration Oral RM1-950 Pharmacology antihistamine Models Biological drugs Article Young Adult chemistry.chemical_compound children Piperidines Pharmacokinetics Humans Medicine Computer Simulation Pharmacology (medical) Dosing Young adult education Aged Aged 80 and over Bilastine education.field_of_study model Clinical Trials Phase I as Topic Dose-Response Relationship Drug business.industry Research Age Factors Articles Middle Aged chemistry Modeling and Simulation Histamine H1 Antagonists Benzimidazoles Female Therapeutics. Pharmacology Efflux business pharmacokinetics absorption |
Zdroj: | CPT: Pharmacometrics & Systems Pharmacology Addi. Archivo Digital para la Docencia y la Investigación instname CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1006-1017 (2021) |
ISSN: | 2163-8306 |
Popis: | The objective of this study was to evaluate bilastine dosing recommendations in older adults and overcome the limitation of insufficient data from phase I studies in this underrepresented population. This was achieved by integrating bilastine physicochemical, in vitro and in vivo data in young adults and the effect of aging in the pharmacology by means of two alternative approaches: a physiologically-based pharmacokinetic (PBPK) model and a semi-mechanistic population pharmacokinetic (Senescence) model. Intestinal apical efflux and basolateral influx transporters were needed in the PBPK model to capture the observations from young adults after single i.v. (10 mg) and p.o. (20 mg) doses, supporting the hypothesis of involvement of gut transporters on secretion. The model was then used to extrapolate the pharmacokinetics (PKs) to elderly subjects considering their specific physiology. Additionally, the Senescence model was develop starting from a published population PK) model, previously applied for pediatrics, and incorporating declining functions on different physiological systems and changes in body composition with aging. Both models were qualified using observed data in a small group of young elderlies (N = 16, mean age = 68.69 years). The PBPK model was further used to evaluate the dose in older subjects (mean age = 80 years) via simulation. The PBPK model supported the hypothesis that basolateral influx and apical efflux transporters are involved in bilastine PK. Both, PBPK and Senescence models indicated that a 20 mg q.d. dose is safe and effective for geriatrics of any age. This approach provides an alternative to generate supplementary data to inform dosing recommendations in under-represented groups in clinical trials. The authors would like to acknowledge financial support from grant 00102201/INNO- 20f171110 from the INNOGLOBAL program of the Centre for the Development of Industrial Technology (CDTI) from the Spanish Ministry of Economy Industry and Competitiveness. |
Databáze: | OpenAIRE |
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