Evaluation of Rifaximin in Management of Hepatic Encephalopathy
| Autor: | Wahib Aa, Diaa Mohammad El-Tiby, El-Sayed Am, El-Deen Salem Mn, Ahmed Ma, Yasser M. M. El-Dessouky, El-Mola K |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class medicine.medical_treatment Antibiotics Enema Gastroenterology Rifaximin law.invention Lactulose chemistry.chemical_compound Anti-Infective Agents Randomized controlled trial law Internal medicine medicine Humans Hepatic encephalopathy Asterixis business.industry medicine.disease Rifamycins chemistry Hepatic Encephalopathy Population study Female medicine.symptom business medicine.drug |
| Zdroj: | Journal of the Egyptian Society of Parasitology. 44:677-685 |
| ISSN: | 1110-0583 |
| DOI: | 10.12816/0007871 |
| Popis: | This study evaluated the efficacy of rifaximin versus lactulose in the treatment of hepatic encephalopathy (HE). The study population included 50 patients who were diagnosed to have signs of the first to third degree HE, according to the West Haven criteria and classified into two groups. GI: included 25 patients who had HE and were treated with lactulose syrup (laxolac) 90 ml daily divided into 3 doses for 7 days. GII: included 25 patients who had HE and were treated with rifaximin 1200 mg daily divided into 3 doses for 7 days. Patients in both groups also received other measures of treatment of HE as daily enema and protein restriction. Rifaximin significantly improved various subjective and measurable components of HE including mental status, behavior, asterixis, and serum ammonia concentration. In acute HE of grade 1 to grade 3, rifaximin may be a good alternative to non-absorbable disaccharides as it is broad spectrum, non-absorbable antibiotic with rapid action and little side effects. It is better tolerated, associated with less frequent and shorter hospitalization in comparison to lactulose. |
| Databáze: | OpenAIRE |
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