Vaccines for the prevention of cardiovascular disease
| Autor: | Una S. Ryan, Charles W. Rittershaus |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Arteriosclerosis Physiology Molecular Sequence Data Drug Evaluation Preclinical Disease Antibodies Immune system Cholesterylester transfer protein medicine Animals Humans Amino Acid Sequence Risk factor Intensive care medicine Randomized Controlled Trials as Topic Pharmacology Vaccines biology business.industry Public health Cholesterol HDL Coronary heart disease Cholesterol Ester Transfer Proteins Cardiovascular Diseases Immunology biology.protein Molecular Medicine Female lipids (amino acids peptides and proteins) Rabbits Peptides business Developed country |
| Zdroj: | Vascular Pharmacology. 45:253-257 |
| ISSN: | 1537-1891 |
| DOI: | 10.1016/j.vph.2006.08.004 |
| Popis: | Atherosclerosis, especially coronary heart disease (CHD), remains a most significant global public health problem. Highly effective LDL-lowering therapies have gained widespread adoption in the United States and throughout the developed world, but therapeutic options for raising low HDL, a key independent risk factor for CHD, remain limited. We are developing a vaccine approach to raising HDL, by inducing an immune response to endogenous cholesteryl ester transfer protein (CETP), and have demonstrated proof of principle in preclinical and clinical models. This vaccine approach may offer the opportunity to address low HDL with a cost-effective semi-annual injection. |
| Databáze: | OpenAIRE |
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