Ethnic and geographic diversity of chronic lymphocytic leukaemia
| Autor: | N. O. Akinola, Robert Peter Gale, Shenmiao Yang, Nitin Sood, Carlos Chiattone, Abraham M Varghese, Xiao-Jun Huang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Cancer Research Population Ethnic group Biology Global Health White People 03 medical and health sciences 0302 clinical medicine immune system diseases Risk Factors hemic and lymphatic diseases Genetic variation Global health medicine Ethnicity Humans Genetic Predisposition to Disease education Clade Aged education.field_of_study Asian Geography Asia Eastern Genome Human Incidence (epidemiology) Incidence Genetic Variation Hematology Middle Aged medicine.disease biology.organism_classification Leukemia Lymphocytic Chronic B-Cell Leukemia 030104 developmental biology Genetics Population Oncology 030220 oncology & carcinogenesis Female Homo erectus Demography |
| Zdroj: | Leukemia. 35(2) |
| ISSN: | 1476-5551 |
| Popis: | East Asians, Asian Indians and Amerindians have a five to ten-fold lower age-adjusted incidence rate (AAIR) of chronic lymphocytic leukaemia (CLL) compared with persons of predominately European descent. The data we review suggest a genetic rather than environmental basis for this discordance. All these populations arose from a common African Black ancestor but different clades have different admixture with archaic hominins including Neanderthals, Denisovans and Homo erectus, which may explain different CLL incidences. There are also some differences in clinical laboratory and molecular co-variates of CLL between these populations. Because the true age-adjusted incidence rate in African Blacks is unknown it is not possible to determine whether modern Europeans acquired susceptibility to CLL or the other populations lost susceptibility and/or developed resistance to developing CLL. We also found other B-cell lymphomas and T- and NK-cell cancers had different incidences in the populations we studied. These data provide clues to determining the cause(s) of CLL. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink