The germline repertoire of T-cell receptor beta-chain genes in patients with multiple sclerosis
| Autor: | Patrick Concannon, Patrick Charmley, Richard A. Gatti, Leroy Hood, William E. Biddison, Henry F. McFarland, Steven S. Beall, Dale E. McFarlin |
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| Rok vydání: | 1989 |
| Předmět: |
Genetics
Multiple Sclerosis Multiple sclerosis Receptors Antigen T-Cell alpha-beta Immunology Haplotype T-cell receptor Receptors Antigen T-Cell Biology medicine.disease Molecular biology Germline Gene Frequency Haplotypes Gene duplication medicine Humans Restriction fragment length polymorphism Allele Gene Alleles |
| Zdroj: | Research in immunology. 140(2) |
| ISSN: | 0923-2494 |
| Popis: | The T-cell receptor (TCR) beta-chain gene repertoire of 40 multiple sclerosis (MS) patients was compared to that of 100 normal individuals. V-beta probes that represent 14 different V-beta sub-families plus a C-beta probe were used to identify 53 separate beta-chain gene segments. No duplication or deletion of any of these 53 gene segments was found in the MS patients. Restriction fragment length polymorphism (RFLP) alleles detected by V-beta 8, V-beta 11 and C-beta probes defined 8 different beta-chain haplotypes. The distribution of these haplotypes in Caucasian MS patients and normal individuals was significantly different (p = 0.012). Comparison of the DR2+ subset of MS patients (n = 32) to a second group of 43 Caucasian DR2+ normal individuals revealed that the distribution of these beta-chain haplotypes was significantly different in these two populations (p = 0.015). These results suggest that an MS susceptibility gene(s) may be located in the region of the TCR/beta-chain gene complex. |
| Databáze: | OpenAIRE |
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