Primary tumour size is a prognostic parameter in patients suffering from differentiated thyroid carcinoma with extrathyroidal growth: results of the MSDS trial
| Autor: | Krämer, Jan Alexander, Schmid, Kurt Werner, Dralle, Henning, Dietlein, Markus, Schicha, Harald, Lerch, Hartmut, Gerß, Joachim, Frankewitsch, Thomas, Schober, Otmar, Riemann, Burkhard, MSDS study group |
|---|---|
| Přispěvatelé: | University of Zurich |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis Endocrinology Diabetes and Metabolism Medizin 610 Medicine & health Disease-Free Survival Thyroid carcinoma Young Adult Endocrinology Internal medicine Follicular phase medicine Humans Tumor type In patient Thyroid Neoplasms Thyroid cancer business.industry Cancer General Medicine 10181 Clinic for Nuclear Medicine Middle Aged medicine.disease 1310 Endocrinology 2712 Endocrinology Diabetes and Metabolism Multivariate Analysis Female Primary tumour size business |
| Popis: | ObjectiveThe Multicentre Study Differentiated Thyroid Cancer (MSDS) collective represents a well-defined group of patients with thyroid carcinomas with extrathyroidal extension. The aim of the present study was to evaluate the relationship of the primary tumour size with clinicopathological features as well as the outcome of patients with minimum and extensive extrathyroidal growth (pT3b- and pT4a-tumours; UICC 2002/2003, 6th ed).MethodsThe tumour diameter was available in 324 out of 351 MSDS patients (244 females, 80 males). Mean age of patients was 47.7±12.0 years (range, 20.1–69.8 years), and the median follow-up was 6.2 years. The relationship between primary tumour size and the following clinicopathological data was investigated: age, gender, histological tumour type (papillary thyroid carcinomas (PTC) versus follicular thyroid carcinomas (FTC)) and UICC/AJCC TNM classification. In addition, the correlation between primary tumour size and event-free and overall survival was assessed.ResultsThe FTC of our series were significantly larger than PTC (3.46 vs 1.84 cm;PP2 cm. Furthermore, event-free and overall survival were significantly correlated with increasing tumour size (P2 cm remained independent predictors of survival.ConclusionsIn patients suffering from differentiated thyroid carcinoma with extrathyroidal growth (pT3b and pT4a), the tumour size is an independent predictor of event-free and overall survival. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|