Increased urinary nitrite excretion in children with minimal change nephrotic syndrome
| Autor: | Jennifer Tomczak, Stephen Futterweit, Andrea Goldstein, Rachel M. Frank, Howard Trachtman, Bernard Gauthier |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Nephrosis Urinary system Remission Spontaneous Gastroenterology Nitric oxide Excretion chemistry.chemical_compound Focal segmental glomerulosclerosis Adrenal Cortex Hormones Recurrence Internal medicine Medicine Humans Child Nitrites business.industry Glomerulosclerosis Focal Segmental Nephrosis Lipoid Glomerulosclerosis Infant Glomerulonephritis Glomerulonephritis IGA medicine.disease Endocrinology chemistry Child Preschool Creatinine Pediatrics Perinatology and Child Health Female Nitric Oxide Synthase business Nephrotic syndrome |
| Zdroj: | The Journal of pediatrics. 128(2) |
| ISSN: | 0022-3476 |
| Popis: | We tested the hypothesis that nitric oxide synthesis by the kidney is increased in children with primary nephrotic syndrome.We examined the urinary excretion of nitrite, a stable metabolite of nitric oxide, using the Griess reaction, in children with nephrotic syndrome.In comparison with healthy children, patients with minimal change nephrotic syndrome had increased urinary nitrite excretion regardless of whether the disease was in relapse or remission (p0.025). In contrast, urinary nitrite excretion was similar in control subjects and patients with focal segmental glomerulosclerosis or IgA nephropathy.These findings indicate that measurement of urinary nitrite excretion may be a useful test to help discriminate between minimal change nephrotic syndrome and focal segmental glomerulosclerosis in children with idiopathic nephrotic syndrome. |
| Databáze: | OpenAIRE |
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