Low arterial pressure during cardiopulmonary bypass in piglets does not decrease fluid leakage
| Autor: | Paul Husby, M. Farstad, Venny Lise Kvalheim, S. E. Rynning, Arve Mongstad, Oddbjørn Haugen |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Nitroprusside Oncotic pressure Extracorporeal Circulation Mean arterial pressure Central Venous Pressure Swine Vasodilator Agents Hydrostatic pressure Blood Pressure Body Water Osmotic Pressure Interstitial fluid Albumins Animals Medicine Plasma Volume Carbon Monoxide Sex Characteristics Blood Volume Cardiopulmonary Bypass business.industry Extracorporeal circulation Hemodynamics Central venous pressure Proteins Extracellular Fluid General Medicine Extravasation Body Fluids Anesthesiology and Pain Medicine Blood pressure Anesthesia Female Vascular Resistance business Algorithms |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 49:1255-1262 |
| ISSN: | 1399-6576 0001-5172 |
| Popis: | Background: Cardiopulmonary bypass (CPB) is associated with increased fluid filtration occasionally leading to post-operative organ dysfunction. One of the factors determining fluid filtration is the capillary hydrostatic pressure which depends on arterial pressure, venous pressure and pre- to post-capillary resistance ratio. The purpose of this study was to assess whether lowering of the mean arterial pressure and/or the central venous pressure could reduce fluid extravasation during normothermic and hypothermic CPB. Methods: Seven piglets were given nitroprusside to a mean arterial pressure of 35–40 mmHg during 60 min of normothermic and 90 min of hypothermic CPB (LP group). They were compared with a control group (C group, n = 7) without blood pressure interventions. Blood chemistry, net fluid balance, plasma volume, colloid osmotic pressure in plasma and interstitial fluid, intravascular protein masses, fluid extravasation rate and total tissue water content were measured or calculated. Results: Mean arterial pressure was significantly lower in the LP group than in the C group during CPB. Plasma volume tended to increase in the LP group (P > 0.05), but remained essentially unchanged in the C group. Net fluid balance in the LP group was more positive than in the C group 30 min after CPB start [1.02 (0.15) vs. 0.56 (0.13) ml/kg/min (Mean (SEM) P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|