A mathematical model of intrahost pneumococcal pneumonia infection dynamics in murine strains
| Autor: | Gilles Clermont, Sarah Lukens, David Swigon, G. Bard Ermentrout, Ericka Mochan |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Statistics and Probability
Serotype Phagocytosis Mice Inbred Strains Biology medicine.disease_cause Models Biological Article General Biochemistry Genetics and Molecular Biology Microbiology Immune system Streptococcus pneumoniae medicine Animals Lung Principal Component Analysis General Immunology and Microbiology Streptococcus Applied Mathematics Bacterial pneumonia Reproducibility of Results General Medicine Pneumonia Pneumococcal medicine.disease Disease Models Animal Modeling and Simulation Host-Pathogen Interactions Pneumococcal pneumonia Immunology General Agricultural and Biological Sciences Pneumonia (non-human) |
| Zdroj: | Journal of Theoretical Biology. 353:44-54 |
| ISSN: | 0022-5193 |
| DOI: | 10.1016/j.jtbi.2014.02.021 |
| Popis: | The seriousness of pneumococcal pneumonia in mouse models has been shown to depend both on bacterial serotype and murine strain. We here present a simple ordinary differential equation model of the intrahost immune response to bacterial pneumonia that is capable of capturing diverse experimentally determined responses of various murine strains. We discuss the main causes of such differences while accounting for the uncertainty in the estimation of model parameters. We model the bacterial population in both the lungs and blood, the cellular death caused by the infection, and the activation and immigration of phagocytes to the infected tissue. The ensemble model suggests that inter-strain differences in response to streptococcus pneumonia inoculation reside in the strength of nonspecific immune response and the rate of extrapulmonary phagocytosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect