Immunoreactivity of Canine Mammary Neoplasms with Monoclonal Antibody CC49
| Autor: | R. Shahar, S. Schneebaum, M. H. Shamir, A. Harmelin |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Pathology
medicine.medical_specialty Antibodies Neoplasm medicine.drug_class Biopsy Mammary Neoplasms Animal Adenocarcinoma Monoclonal antibody Stain Pathology and Forensic Medicine Dogs Mammary Glands Animal Monoclonal antibody CC49 Antigen Antigens Neoplasm medicine Animals Humans Neoplasm Dog Diseases Glycoproteins chemistry.chemical_classification General Veterinary Immunoperoxidase biology Antibodies Monoclonal medicine.disease Molecular biology chemistry biology.protein Female Antibody Glycoprotein |
| Zdroj: | Journal of Veterinary Medicine Series A. 44:317-323 |
| ISSN: | 1439-0442 0931-184X |
| DOI: | 10.1111/j.1439-0442.1997.tb01116.x |
| Popis: | Monoclonal antibody (MAb) CC49 binds to human tumour-associated glycoprotein termed TAG-72. CC49 is a second-generation MAb with higher affinity to TAG-72 than the original MAb B72.3. CC49 was applied to 42 samples from different canine mammary tumours, belonging to seven different histopathological types. Immunoreactivity was detected by the use of an avidin-biotin complex immunoperoxidase method. Most sections from all types of mammary neoplasm reacted with this MAb. Normal tissue did not stain or stained only weakly. The results of this study suggest CC49 has selective immunoreactivity for a variety of canine mammary tumours, which seems superior to that reported with MAb 72.3. These results support the proposal for further study of diagnostic and therapeutic uses of CC49 in the management of canine mammary tumours. |
| Databáze: | OpenAIRE |
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