Inflammation and Alzheimer's disease pathogenesis
| Autor: | Patrick C. McGeer, Libuse Brachova, Scott E. Webster, Joseph Rogers, Mark Emmerling, Douglas G. Walker, Lih-Fen Lue, Brenda Shivers, W. Harold Civin |
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| Rok vydání: | 1996 |
| Předmět: |
Brain Chemistry
Inflammation Aging business.industry Mechanism (biology) General Neuroscience Anti-Inflammatory Agents Non-Steroidal Neurodegeneration Disease medicine.disease Pathogenesis Degenerative disease Alzheimer Disease Immunology Humans Medicine Dementia Neurology (clinical) Inflammation Mediators Geriatrics and Gerontology Alzheimer's disease medicine.symptom business Developmental Biology |
| Zdroj: | Neurobiology of Aging. 17:681-686 |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/0197-4580(96)00115-7 |
| Popis: | Appreciation of the role that inflammatory mediators play in Alzheimer's disease (AD) pathogenesis continues to be hampered by two related misconceptions. The first is that to be pathogenically significant a neurodegenerative mechanism must be primary. The second is that inflammation merely occurs to clear the detritis of already existent pathology. The present review addresses these issues by showing that 1) inflammatory molecules and mechanisms are uniquely present or significantly elevated in the AD brain, 2) inflammation may be a necessary component of AD pathogenesis, 3) inflammation may be sufficient to cause AD neurodegeneration, and 4) retrospective and direct clinical trials suggest a therapeutic benefit of conventional antiinflammatory medications in slowing the progress or even delaying the onset of AD. |
| Databáze: | OpenAIRE |
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