D-penicillamine-induced myasthenia gravis: diagnosis obscured by coexisting chronic obstructive pulmonary disease
| Autor: | Paul M. Wallach, P. R. Winters, Adelman Hm, C. S. Mahan |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Weakness Arthritis Arthritis Rheumatoid Myasthenia Gravis medicine Humans Lung Diseases Obstructive Aged business.industry Respiratory disease Penicillamine General Medicine Hypoventilation Middle Aged medicine.disease Dermatology Obstructive lung disease Myasthenia gravis Surgery Respiratory failure Rheumatoid arthritis Female medicine.symptom business Respiratory Insufficiency |
| Zdroj: | The American journal of the medical sciences. 309(4) |
| ISSN: | 0002-9629 |
| Popis: | D-penicillamine, a drug used to treat rheumatoid arthritis, Wilson's disease, and cystinuria, can cause myasthenia gravis. Fortunately, the myasthenia typically resolves after discontinuation of the drug. The diagnosis may be missed if weakness is blamed on a patient's underlying disease(s), in particular, rheumatoid arthritis. Reported here are the cases of two patients with chronic obstructive lung disease who were taking D-penicillamine for rheumatoid arthritis, then experienced increasing respiratory failure. At first, their problem seemed to stem from chronic lung disease, but further evaluation revealed the cause of the hypoventilation to be D-penicillamine-induced myasthenia gravis. |
| Databáze: | OpenAIRE |
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