Diagnostic and prognostic correlates of preoperative FDG PET for breast cancer
| Autor: | Hilde Van Parijs, Hansjoerg Vees, Vincent Vinh-Hung, Marian Vanhoeij, Mia Voordeckers, Mark De Ridder, Hendrik Everaert, Christel Fontaine, Jan Lamote, Guy Verfaillie, Georges Vlastos, Osman Ratib |
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| Přispěvatelé: | Internal Medicine Specializations, Faculty of Medicine and Pharmacy, Radiation Therapy, Translational Radiation Oncology and Physics, Medical Imaging and Physical Sciences, Surgery Specializations, Surgical clinical sciences, Surgery, Laboratory of Molecular and Medical Oncology |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Lymphatic metastasis Preoperative care ddc:616.0757 Breast Neoplasms Male evaluation studies Breast cancer Fluorodeoxyglucose F18 Internal medicine Preoperative Care breast neoplasms medicine Humans Radiology Nuclear Medicine and imaging Radiopharmaceuticals/diagnostic use skin and connective tissue diseases Retrospective Studies ddc:618 business.industry Breast Neoplasms Male/radionuclide imaging/surgery General Medicine Middle Aged medicine.disease Prognosis humanities carbohydrates (lipids) body regions Fluorodeoxyglucose F18/diagnostic use Lymphatic Metastasis Positron-Emission Tomography Female Radiology Radiopharmaceuticals business |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging, Vol. 39, No 10 (2012) pp. 1618-27 |
| ISSN: | 1619-7070 |
| Popis: | PURPOSE: To explore the preoperative utility of FDG PET for the diagnosis and prognosis in a retrospective breast cancer case series. METHODS: In this retrospective study, 104 patients who had undergone a preoperative FDG PET scan for primary breast cancer at the UZ Brussel during the period 2002-2008 were identified. Selection criteria were: histological confirmation, FDG PET performed prior to therapy, and breast surgery integrated into the primary therapy plan. Patterns of increased metabolism were recorded according to the involved locations: breast, ipsilateral axillary region, internal mammary chain, or distant organs. The end-point for the survival analysis using Cox proportional hazards was disease-free survival. The contribution of prognostic factors was evaluated using the Akaike information criterion and the Nagelkerke index. RESULTS: PET positivity was associated with age, gender, tumour location, tumour size >2 cm, lymphovascular invasion, oestrogen and progesterone receptor status. Among 63 patients with a negative axillary PET status, 56 (88.9 %) had three or fewer involved nodes, whereas among 41 patients with a positive axillary PET status, 25 (61.0 %) had more than three positive nodes (P < 0.0001). In the survival analysis of preoperative characteristics, PET axillary node positivity was the foremost statistically significant factor associated with decreased disease-free survival (hazard ratio 2.81, 95% CI 1.17-6.74). CONCLUSION: Preoperative PET axillary node positivity identified patients with a higher burden of nodal involvement, which might be important for treatment decisions in breast cancer patients. |
| Databáze: | OpenAIRE |
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