A pilot interventional study to evaluate the impact of cholecalciferol treatment on HbA1c in type 1 diabetes (T1D)
| Autor: | S Ainsworth, Andrew Whatmore, Philip Murray, Adam Stevens, Peter E. Clayton, M Marshall, I Doughty, Judith Campbell, Lucia Magee, M Z Mughal, Fiona Ivison, Sarah Ehtisham, Reena Perchard |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
HbA1c Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism vitamin D bone lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Maintenance therapy Internal medicine Diabetes mellitus Internal Medicine medicine Vitamin D and neurology 030212 general & internal medicine Vitamin D Bone Type 1 diabetes lcsh:RC648-665 diabetes business.industry Research Significant difference Diabetes medicine.disease Paediatric endocrinology Surgery chemistry Sample size determination Cohort Cholecalciferol business paediatric endocrinology |
| Zdroj: | Endocrine Connections, Vol 6, Iss 4, Pp 225-231 (2017) Endocrine Connections Perchard, R, Magee, L, Whatmore, A, Ivison, F, Murray, P, Stevens, F, Mughal, M Z, Ehtisham, S, Campbell, J, Ainsworth, S, Marshall, M, Bone, M, Doughty, I & Clayton, P 2017, ' A Pilot Interventional Study to Evaluate the Impact of Cholecalciferol Treatment on HbA1c in Type 1 Diabetes (T1D) ', Endocrine Connections, vol. 6, no. 4, pp. 225-231 . https://doi.org/10.1530/EC-17-0045, https://doi.org/10.1530/EC-17-0045 |
| ISSN: | 2049-3614 |
| DOI: | 10.1530/EC-17-0045 |
| Popis: | Background Higher 25(OH)D3 levels are associated with lower HbA1c, but there are limited UK interventional trials assessing the effect of cholecalciferol on HbA1c. Aims (1) To assess the baseline 25(OH)D3 status in a Manchester cohort of children with type 1 diabetes (T1D). (2) To determine the effect of cholecalciferol administration on HbA1c. Methods Children with T1D attending routine clinic appointments over three months in late winter/early spring had blood samples taken with consent. Participants with a 25(OH)D3 level 10 years) units. HbA1c levels before and after treatment were recorded. Results Vitamin D levels were obtained from 51 children. 35 were Caucasian, 11 South Asian and 5 from other ethnic groups. 42 were vitamin D deficient, but 2 were excluded from the analysis. All South Asian children were vitamin D deficient, with mean 25(OH)D3 of 28 nmol/L. In Caucasians, there was a negative relationship between baseline 25(OH)D3 level and HbA1c (r = −0.484, P t = 1.010, P = 0.328) or at 1 year (t = −1.173, P = 0.248) before and after treatment. One-way ANCOVA, controlling for age, gender, ethnicity, BMI and diabetes duration showed no difference in Δ HbA1c level. Conclusion We report important findings at baseline, but in children treated with a stat dose of cholecalciferol, there was no effect on HbA1c. Further studies with larger sample sizes and using maintenance therapy are required. |
| Databáze: | OpenAIRE |
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