Metabolic Effects of Bovine Milk Oligosaccharides on Selected Commensals of the Infant Microbiome - Commensalism and Postbiotic Effects
| Autor: | Ulrik Kræmer Sundekilde, Maria X. Maldonado-Gomez, Louise M. A. Jakobsen, Hanne Christine Bertram, Henrik J. Andersen, Dennis Sandris Nielsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Bifidobacterium longum Endocrinology Diabetes and Metabolism 030106 microbiology lcsh:QR1-502 Gut microbiota Gut flora metabolic activity medicine.disease_cause Biochemistry Article lcsh:Microbiology Microbiology Infant nutrition Microbial interaction 03 medical and health sciences chemistry.chemical_compound microbial interaction fluids and secretions medicine Microbiome Lactose Molecular Biology 0000-0002-0544-7464 biology gut microbiota infant nutrition food and beverages Clostridium perfringens biology.organism_classification co-culture 030104 developmental biology chemistry Metabolic activity Parabacteroides distasonis bacteria Fermentation Co-culture Bacteria |
| Zdroj: | Jakobsen, L M A, Maldonado-Gómez, M X, Sundekilde, U K, Andersen, H J, Nielsen, D S & Bertram, H C 2020, ' Metabolic Effects of Bovine Milk Oligosaccharides on Selected Commensals of the Infant Microbiome-Commensalism and Postbiotic Effects ', Metabolites, vol. 10, no. 4, 167 . https://doi.org/10.3390/metabo10040167 Metabolites, Vol 10, Iss 167, p 167 (2020) Jakobsen, L M A, Maldonado-Gómez, M X, Sundekilde, U K, Andersen, H J, Nielsen, D S & Bertram, H C S 2020, ' Metabolic Effects of Bovine Milk Oligosaccharides on Selected Commensals of the Infant Microbiome : Commensalism and Postbiotic Effects ', Metabolites, vol. 10, no. 4, 167 . https://doi.org/10.3390/metabo10040167 Metabolites Volume 10 Issue 4 |
| DOI: | 10.3390/metabo10040167 |
| Popis: | Oligosaccharides from human or bovine milk selectively stimulate growth or metabolism of bacteria associated with the lower gastrointestinal tract of infants. Results from complex infant-type co-cultures point toward a possible synergistic effect of combining bovine milk oligosaccharides (BMO) and lactose (LAC) on enhancing the metabolism of Bifidobacterium longum subsp. longum and inhibition of Clostridium perfringens. We examine the interaction between B. longum subsp. longum and the commensal Parabacteroides distasonis, by culturing them in mono- and co-culture with different carbohydrates available. To understand the interaction between BMO and lactose on B. longum subsp. longum and test the potential postbiotic effect on C. perfringens growth and/or metabolic activity, we inoculated C. perfringens into fresh media and compared the metabolic changes to C. perfringens in cell-free supernatant from B. longum subsp. longum fermented media. In co-culture, B. longum subsp. longum benefits from P. distasonis (commensalism), especially in a lactose-rich environment. Furthermore, B. longum subsp. longum fermentation of BMO + LAC impaired C. perfringens&rsquo ability to utilize BMO as a carbon source (potential postbiotic effect). |
| Databáze: | OpenAIRE |
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