Influence ofMBL-2mutations in the infection risk of patients with follicular lymphoma treated with rituximab, fludarabine, and cyclophosphamide

Autor:	Joaquin Martínez-López, Ana Rivero, Inmaculada Rapado, Carlos Montalbán, Jose Paz-Carreira, Miguel Canales, Rafael Martínez, Pedro Sánchez-Godoy, Alberto Fernández de Sevilla, Francisco J. Peñalver, Marcos Gonzalez, Elena Prieto, Antonio Salar, Carmen Burgaleta, Jose A. Queizán, Maria J. Peñarrubia, Maria D. Monteagudo, Carmen Cabrera, Javier De la Serna, José F. Tomás
Rok vydání:	2009
Předmět:	Adult Male Risk Cancer Research Neutropenia Cyclophosphamide medicine.medical_treatment Follicular lymphoma Disease Infections Malignancy Mannose-Binding Lectin Antibodies Monoclonal Murine-Derived Young Adult Clinical Trials Phase II as Topic Anti-Infective Agents Gene Frequency Lymphopenia Antineoplastic Combined Chemotherapy Protocols medicine Humans Multicenter Studies as Topic Genetic Predisposition to Disease Prospective Studies Lymphoma Follicular Alleles Aged Chemotherapy business.industry Antibodies Monoclonal Genetic Variation Hematology Immunotherapy Middle Aged medicine.disease Lymphoma Haplotypes Oncology Spain Early Termination of Clinical Trials Immunology Female Rituximab business Vidarabine medicine.drug
Zdroj:	Leukemia & Lymphoma. 50:1283-1289
ISSN:	1029-2403 1042-8194
DOI:	10.1080/10428190903040006
Popis:	The employment of current treatments based on chemotherapy and immunotherapy leads to inmunosuppression. The presence of mutations or polymorphisms in genes related to immune system might involve an additional disadvantage. The aim of the present study was to analyze mannose-binding lectin (MBL-2 gene) mutations and their association with severe infections and event-free survival in patients diagnosed with follicular lymphoma, treated uniformly, in the clinical trial LNHF-03. The results of this trial showed impressive clinical efficacy but was complicated with 80 documented infectious episodes. Patients were classified into two genotypic groups, AA and AO/OO, based on their haplotypic inheritance. Neither the number of infectious episodes nor differences in event-free survival was found as a function of MBL-2 groups. Other factors, including the lymphoma malignancy and the immune alterations associated with the disease, should be considered responsible for this observation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862bcacb6a3c39aee0dfe21e0d568978 https://doi.org/10.1080/10428190903040006 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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