Risk factors for new-onset diabetes mellitus after kidney transplantation (NODAT): a Brazilian single center study

Autor: Thelma L. Skare, Camila Ferreira Lima, Renato Nisihara, Paulo Jaworski, Amanda Grden
Jazyk: angličtina
Předmět:
Adult
Male
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
030232 urology & nephrology
lcsh:Medicine
030230 surgery
Single Center
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Statistics
Nonparametric
Tacrolimus
03 medical and health sciences
Postoperative Complications
0302 clinical medicine
Risk Factors
Internal medicine
Diabetes mellitus
renal transplant
medicine
Humans
Kidney transplantation
Dyslipidemias
Retrospective Studies
Univariate analysis
lcsh:RC648-665
business.industry
Incidence
Incidence (epidemiology)
New-onset diabetes after transplantation (NODAT)
lcsh:R
Retrospective cohort study
Middle Aged
medicine.disease
Kidney Transplantation
calcineurin inhibitors
Logistic Models
Hypertension
diabetes mellitus
Female
business
Body mass index
Brazil
Immunosuppressive Agents
Dyslipidemia
Zdroj: Archives of Endocrinology and Metabolism, Vol 62, Iss 6, Pp 597-601
Archives of Endocrinology and Metabolism v.62 n.6 2018
Arquivos de Endocrinologia e Metabolismo
Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
ISSN: 2359-4292
Popis: Objectives: This study aims to verify the new-onset diabetes after kidney transplant (NODAT) incidence in recipients within 1 year after kidney transplantation from a single center in Southern Brazil and to assess the associated conditions. Subjects and methods: A retrospective study of 258 post-renal transplant patients was performed. Demographic (gender, age, ethnic background) and clinical (origin of graft, associated infections, body mass index (BMI) at transplant time and 6 and 12 months after, causes of renal failure, and comorbidities) data were analyzed. All patients were on tacrolimus, mycophenolate mofetil, and prednisone treatment. Patients with and without NODAT were compared. Results: A NODAT incidence of 31.2% was noted 1 year post transplantation. In the univariate analysis, patients with NODAT were older (p = 0.001), mostly had African–American ethnic background (p = 0.02), and had renal failure secondary to high blood pressure (HBP) (p = 0.001). The group of patients with NODAT also had more incidence of post-transplant HBP (p = 0.01), heart failure (p = 0.02), and dyslipidemia (p = 0.001). Logistic regression showed that African–American ethnic background, post-transplant HBP, and dyslipidemia were independently associated with NODAT. Conclusion: This study shows a NODAT incidence that is greater in patients with African–American ethnic background and that is associated with HBP and dyslipidemia.
Databáze: OpenAIRE
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