The association of microhematuria with mesangial hypercellularity, endocapillary hypercellularity, crescent score and renal outcomes in immunoglobulin A nephropathy
| Autor: | Lisa E. Vaughan, Richard J. Glassock, Ladan Zand, Lynn D. Cornell, Sanjeev Sethi, Ranine Ghamrawi, Shane A. Bobart, Fernando C. Fervenza, Khaled Shawwa, Mariam P. Alexander |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Biopsy Urology Renal function Mesangial hypercellularity urologic and male genital diseases Kidney medicine Humans Endocapillary hypercellularity Microhematuria Retrospective Studies Transplantation Proteinuria Sclerosis medicine.diagnostic_test Surrogate endpoint business.industry Retrospective cohort study Glomerulonephritis IGA Original Articles Middle Aged medicine.icd_9_cm_classification Fibrosis Nephrology Kidney Failure Chronic medicine.symptom business Glomerular Filtration Rate |
| Zdroj: | Nephrol Dial Transplant |
| Popis: | Background Microhematuria is common in immunoglobulin A nephropathy (IgAN). However, current prognostication is based on proteinuria and mesangial hypercellularity, endocapillary hypercellularity, segmental sclerosis, tubulointerstitial fibrosis and crescent (MEST-C) scores. Methods In this retrospective study, we evaluated whether MEST-C score components are associated with the presence of microhematuria at biopsy and whether the degree of microhematuria during follow-up is associated with change in estimated glomerular filtration rate (eGFR), after adjusting for clinical and histological parameters. We identified 125 patients with biopsy-proven IgAN and MEST-C scoring who were not on immunosuppressive therapy at biopsy. Microhematuria was defined as ≥3 red blood cells (RBCs)/high-power field (hpf). Results Of the 125 patients, 97 had microhematuria at baseline and were more likely to have M1, E1 and C ≥ 1 lesions (P Conclusion Degree of microhematuria during follow-up is an independent predictor of eGFR decline after adjusting for clinical and histological parameters. Therefore, monitoring the degree of microhematuria as well as proteinuria is important when evaluating patients with IgAN. Additional studies using improvement in microhematuria as a primary surrogate outcome are needed. |
| Databáze: | OpenAIRE |
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