Effects of simvastatin on bone regeneration in the mandibles of ovariectomized rats and on blood cholesterol levels

Autor: Rosilene Fernandes da Rocha, Maria Nadir Gasparoto Mancini, Ivan Balducci, Yasmin Rodarte Carvalho, Juliana Campos Junqueira, Ana Lia Anbinder
Přispěvatelé: Universidade Estadual Paulista (Unesp)
Rok vydání: 2002
Předmět:
Simvastatin
jaw disease
Bone Regeneration
Bone density
Statistics as Topic
Mandible
Wistar rat
hydroxymethylglutaryl coenzyme A reductase inhibitor
chemistry.chemical_compound
Absorptiometry
Photon
Bone Density
Medicine
animal
rat
Densitometry
X-Ray
Polytetrafluoroethylene
radiodensitometry
Anticholesteremic Agents
drug effect
Statistics
hypocholesterolemic agent
Cholesterol
female
Ovariectomized rat
Female
Analysis of variance
medicine.drug
analysis of variance
medicine.medical_specialty
medicine.drug_class
Ovariectomy
tissue regeneration
artificial membrane
blood
Internal medicine
Animals
Mandibular Diseases
Rats
Wistar
Bone regeneration
General Dentistry
Analysis of Variance
Guided Tissue Regeneration
business.industry
cholesterol
politef
Membranes
Artificial
Rats
Endocrinology
chemistry
Estrogen
Blood cholesterol
pathology
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 1880-4926
1343-4934
Popis: Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:20:33Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:39:43Z : No. of bitstreams: 1 2-s2.0-0038048845.pdf: 4251947 bytes, checksum: c052a2306aa5768052f92319e9325e90 (MD5) Made available in DSpace on 2014-05-27T11:20:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2002-12-01 The purpose of this study was to evaluate the effects of simvastatin on guided bone regeneration in the mandibles of ovariectomized rats, and to observe their blood cholesterol levels. Seventy female rats were divided into two groups: control and treated, both groups containing normal and ovariectomized rats. A month after ovariectomy a bone defect was created in the mandible, and was covered by a polytetrafluoroethylene membrane. The treated groups received simvastatin orally for 15 or 30 days. The rats were sacrificed 15, 30 or 60 days after surgery, at which time a blood sample was extracted for blood cholesterol level analysis and the mandible was extracted for densitometric, histological and morphometric analysis. All specimens underwent analysis of variance. The ovariectomized animals had higher cholesterol levels than the treated normal animals, and no significant difference was found between the different treatment periods and the sacrifice times. The densitometric, histological and morphometric analysis showed that the treated ovariectomized animals developed more new bone than the control ovariectomized rats, but no significant difference was observed between the treatment periods. It can be concluded that the deficiency of estrogen increased the level of blood cholesterol and that the simvastatin aided new bone formation in the ovariectomized animals.
Databáze: OpenAIRE
Externí odkaz: