Yellow fever virus spread in Rio de Janeiro and Espírito Santo, 2016-2019: Phylodynamic assessment to improve intervention strategies
| Autor: | Tiago Gräf, Julien Thézé, Fonseca, de Alburque Cfc, Rivaldo Venancio Cunha, Joilson Xavier, dos Santos Cc, Fernandes Ca, Wanderson Kleber de Oliveira, de Mendonça Mcl., Simone Alves Sampaio, de Filippis Amb., Marta Giovanetti, de Abreu Al, Chalhoub Fll., Maria Angélica Mares-Guia, Shirlei Ferreira Aguiar, do Carmo Said Rf, Alexandre Otavio Chieppe, Nuno R. Faria, Patrícia Carvalho de Sequeira, Alcantara Lcj, de Oliveira T, de Bruycker Nogueira F, de Jesus Jg, dos Santos Rodrigues Cd, Daniel Garkauskas Ramos, Allison Fabri, Romano Apm. |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Arbovirus Infections Public health 030231 tropical medicine Yellow fever Outbreak medicine.disease medicine.disease_cause Arbovirus 3. Good health Dengue fever 03 medical and health sciences 0302 clinical medicine Geography Infectious disease (medical specialty) Environmental health medicine Chikungunya 030304 developmental biology |
| DOI: | 10.1101/711994 |
| Popis: | The recent re-emergence of yellow fever virus (YFV) in Brazil has raised serious concerns due to the virus’ rapid dissemination in the southeastern region. To better understand YFV genetic diversity and dynamics during the recent outbreak in southeastern Brazil we generated 18 complete and near-complete genomes from the peak of the epidemic curve from non-human primates (NHPs) and human infected cases across Espírito Santo and Rio de Janeiro states. Genomic sequencing of 18 YFV genomes revealed the timing, source and likely routes of yellow fever virus transmission and dispersion during the one of the largest outbreaks ever registered in Brazil. We showed that the recent YFV epidemic spillover southwards several times from Minas Gerais to Espírito Santo and Rio de Janeiro states in 2016 to 2019. The quick production and analysis of data from portable sequencing could identify the corridor of spread of YFV. These findings reinforce that real-time and continued genomic surveillance strategies can assist in the monitoring and public health responses of arbovirus epidemics.IMPORTANCEArbovirus infections in Brazil including Yellow Fever, Dengue, Zika and Chikungunya result in considerable morbidity and mortality and are pressing public health concerns. However, our understanding of these outbreaks is hampered by limited availability of real time genomic data. In this study, we investigated the genetic diversity and spatial distribution of YFV during the current outbreak in southeastern Brazil. To gain insights into the routes of YFV introduction and dispersion, we tracked the virus by sequencing YFV genomes sampled from non-human primates and infected patients from the southeastern region. Our study provides an understanding of how YFV initiates transmission in new Brazilian regions and illustrates that near-real time genomics in the field can augment traditional approaches to infectious disease surveillance and control. |
| Databáze: | OpenAIRE |
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