REM sleep without atonia and nocturnal body position in prediagnostic Parkinson's disease
| Autor: | Ilse De Volder, Karlien Van den Bossche, Jo leenders, M. Willemen, Nathan Reyn, David Crosiers, Femke Dijkstra, Mineke Viaene, Barbara de Bruyn, Patrick Cras |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Supine position Parkinson's disease Sleep REM REM Sleep Behavior Disorder Polysomnography REM sleep behavior disorder Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders Humans Medicine Tonic (music) Prospective Studies Retrospective Studies Sleep Stages Sleep disorder medicine.diagnostic_test business.industry Parkinson Disease General Medicine medicine.disease Sleep in non-human animals 030228 respiratory system Case-Control Studies Human medicine business psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Sleep medicine |
| ISSN: | 1389-9457 |
| Popis: | Background Sleep disturbances are features of Parkinson's disease (PD), that can already occur before PD diagnosis. The most investigated prodromal PD sleep disorder is REM sleep behavior disorder (RBD). The relation between other polysomnographic (PSG) alterations and the prediagnostic stages of PD, however, is less clear. Methods We performed a retrospective case–control study to characterize polysomnographic alterations in PD and prediagnostic PD. We included 63 PD subjects (33 subjects that underwent a video-PSG before PD diagnosis [13 with and 20 without RBD] and 30 subjects that underwent a PSG after PD diagnosis) and 30 controls. PSGs were analyzed for sleep stages, different RSWA variables, body position, arousals, periodic limb movements, and REM density. Results Higher subscores of all RSWA variables were observed in subjects with PD and prediagnostic PD (with and without RBD). Total RSWA, tonic RSWA and chin RSWA severity were significant predictors for all PD and prediagnostic PD groups. Our study also shows a higher percentage of nocturnal supine body position in all PD and prediagnostic PD groups. Supine body position percentage is the highest in the PD group and has a positive correlation with time since diagnosis. Conclusions These findings suggest that increased total, tonic and chin RSWA as well as nocturnal supine body position are already present in prediagnostic PD, independently of RBD status. Prospective longitudinal studies are necessary to confirm the additional value of these PSG abnormalities as prodromal PD biomarkers. |
| Databáze: | OpenAIRE |
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