Vitamin D and Death by Sunshine
| Autor: | Eric J. Song, Katie M. Dixon, Vanessa B. Sequeira, Sally E. Carter, Clare Gordon-Thomson, Wannit Tongkao-on, Mark S. Rybchyn, Rebecca S. Mason |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
p53
Vitamin ultraviolet radiation Programmed cell death Skin Neoplasms Ultraviolet Rays DNA damage sunburn cells vitamin D Pyrimidine dimer Human skin Review Absorption (skin) Biology Catalysis lcsh:Chemistry Inorganic Chemistry chemistry.chemical_compound Dehydrocholesterols Calcitriol nitric oxide cyclobutane pyrimidine dimers medicine Vitamin D and neurology Humans Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy Cell Death integumentary system AKT Organic Chemistry Vitamins General Medicine medicine.disease MAPK Computer Science Applications lcsh:Biology (General) lcsh:QD1-999 Biochemistry chemistry Sunlight Cancer research Tumor Suppressor Protein p53 Skin cancer 1 25-dihydroxyvitamin D3 DNA Damage |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 14, Iss 1, Pp 1964-1977 (2013) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms14011964 |
| Popis: | Exposure to sunlight is the major cause of skin cancer. Ultraviolet radiation (UV) from the sun causes damage to DNA by direct absorption and can cause skin cell death. UV also causes production of reactive oxygen species that may interact with DNA to indirectly cause oxidative DNA damage. UV increases accumulation of p53 in skin cells, which upregulates repair genes but promotes death of irreparably damaged cells. A benefit of sunlight is vitamin D, which is formed following exposure of 7-dehydrocholesterol in skin cells to UV. The relatively inert vitamin D is metabolized to various biologically active compounds, including 1,25-dihydroxyvitamin D3. Therapeutic use of vitamin D compounds has proven beneficial in several cancer types, but more recently these compounds have been shown to prevent UV-induced cell death and DNA damage in human skin cells. Here, we discuss the effects of vitamin D compounds in skin cells that have been exposed to UV. Specifically, we examine the various signaling pathways involved in the vitamin D-induced protection of skin cells from UV. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|