Loss of Bone Mineral Density Associated with Age in Male Rats Fed on Sunflower Oil Is Avoided by Virgin Olive Oil Intake or Coenzyme Q Supplementation
| Autor: | Magdalena López-Frías, Julio J. Ochoa, Alfonso Varela-López, Elena Planells, Maurizio Battino, José L. Quiles, Lorenza Speranza, José M. Llamas-Elvira |
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| Přispěvatelé: | [Varela-Lopez, Alfonso] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Biomed Res Ctr, Avda Conocimiento S-N, Granada 18016, Spain, [Ochoa, Julio J.] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Biomed Res Ctr, Avda Conocimiento S-N, Granada 18016, Spain, [Lopez-Frias, Magdalena] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Biomed Res Ctr, Avda Conocimiento S-N, Granada 18016, Spain, [Planells, Elena] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Biomed Res Ctr, Avda Conocimiento S-N, Granada 18016, Spain, [Quiles, Jose L.] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Biomed Res Ctr, Avda Conocimiento S-N, Granada 18016, Spain, [Varela-Lopez, Alfonso] Univ Granada, Fac Pharm, Dept Physiol, Calle Prof Clavera S-N, E-18071 Granada, Spain, [Ochoa, Julio J.] Univ Granada, Fac Pharm, Dept Physiol, Calle Prof Clavera S-N, E-18071 Granada, Spain, [Lopez-Frias, Magdalena] Univ Granada, Fac Pharm, Dept Physiol, Calle Prof Clavera S-N, E-18071 Granada, Spain, [Planells, Elena] Univ Granada, Fac Pharm, Dept Physiol, Calle Prof Clavera S-N, E-18071 Granada, Spain, [Quiles, Jose L.] Univ Granada, Fac Pharm, Dept Physiol, Calle Prof Clavera S-N, E-18071 Granada, Spain, [Llamas-Elvira, Jose M.] Hosp Virgen Nieves, Nucl Med Serv, Avda Fuerzas Armadas 2, Granada 18014, Spain, [Speranza, Lorenza] Univ G dAnnunzio, Dept Med & Sci Aging, I-66100 Chieti, Italy, [Battino, Maurizio] Univ Politecn Marche, Dept Sci Clin Specialist & Odontostomatol, I-60131 Ancona, Italy, Spanish Ministry of Education and Science, Autonomous Government of Andalusia |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Eicosapentaenoic acid Ubiquinone Parathyroid hormone medicine.disease_cause F2-isoprostanes Hip fracture Fatty Acids Monounsaturated chemistry.chemical_compound 0302 clinical medicine Bone Density Sunflower Oil oxidative stress Spectroscopy Bone mineral chemistry.chemical_classification Fatty-acids biology General Medicine Antioxidant capacity Computer Science Applications bone mineral density MUFA PUFA Parathyroid Hormone Older-adults Fatty Acids Unsaturated Osteocalcin Polyunsaturated fatty acid musculoskeletal diseases medicine.medical_specialty F-2-isoprostanes food.ingredient Osteoclast differentiation 030209 endocrinology & metabolism Article Catalysis Inorganic Chemistry 03 medical and health sciences Animal science food Adrenocorticotropic Hormone Dietary Fats Unsaturated Osteoprotegerin Internal medicine medicine Bone mineral density Animals Women Rats Wistar Physical and Theoretical Chemistry Olive Oil Molecular Biology Polyunsaturated fatty acids (PUFA) Coenzyme Q10 Clinical epidemiology Sunflower oil RANK Ligand Organic Chemistry Rats 030104 developmental biology Endocrinology chemistry Oxidative stress Dietary Supplements biology.protein Osteoporosis Osteopontin |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 18; Issue 7; Pages: 1397 Digibug. Repositorio Institucional de la Universidad de Granada instname |
| Popis: | The role of dietary fat unsaturation and the supplementation of coenzyme Q have been evaluated in relation to bone health. Male Wistar rats were maintained for 6 or 24 months on two diets varying in the fat source, namely virgin olive oil, rich in monounsaturated fatty acids, or sunflower oil, rich in n-6 polyunsaturated fatty acids. Both dietary fats were supplemented or not with coenzyme Q10 (CoQ10). Bone mineral density (BMD) was evaluated in the femur. Serum levels of osteocalcin, osteopontin, receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), adrenocorticotropin (ACTH) and parathyroid hormone (PTH), as well as urinary F2-isoprostanes were measured. Aged animals fed on virgin olive oil showed higher BMD than those fed on sunflower oil. In addition, CoQ10 prevented the age-related decline in BMD in animals fed on sunflower oil. Urinary F2-isoprostanes analysis showed that sunflower oil led to the highest oxidative status in old animals, which was avoided by supplementation with CoQ10. In conclusion, lifelong feeding on virgin olive oil or the supplementation of sunflower oil on CoQ10 prevented, at least in part mediated by a low oxidative stress status, the age-related decrease in BMD found in sunflower oil fed animals. This work was supported by the Spanish Ministry of Education and Science (AGL2008-01057) and the Autonomous Government of Andalusia (AGR832). |
| Databáze: | OpenAIRE |
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