Alterations in Ionized and Total Blood Magnesium After Experimental Traumatic Brain Injury
| Autor: | Kathryn E. Saatman, Adrienne L. Brown, Grant Sinson, Justin D. Weisser, Tracy K. McIntosh, Mark A. Helfaer, Florence M. Bareyre |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Cations Divalent Traumatic brain injury Magnesium Chloride Poison control chemistry.chemical_element Motor Activity Calcium Nervous System Biochemistry Neuroprotection Rats Sprague-Dawley Cellular and Molecular Neuroscience Cognition Blood plasma medicine Animals Learning Magnesium Calcium metabolism business.industry Head injury medicine.disease Rats chemistry Brain Injuries Anesthesia Nervous System Diseases business |
| Zdroj: | Journal of Neurochemistry. 73:271-280 |
| ISSN: | 0022-3042 |
| DOI: | 10.1046/j.1471-4159.1999.0730271.x |
| Popis: | Experimental evidence suggests that magnesium plays a role in the pathophysiological sequelae of brain injury. The present study examined the variation of blood ionized and total magnesium, as well as potassium, sodium, and ionized calcium, after experimental fluid percussion brain injury in rats. Blood ionized magnesium concentration significantly declined from 0.45 +/- 0.02 to 0.32 +/- 0.02 mM by 30 min postinjury and stayed depressed for the 24-h study period in vehicle-treated rats. Blood total magnesium concentration was 0.59 +/- 0.01 mM and remained stable over time in brain-injured vehicle-treated animals. When magnesium chloride (125 micromol/rat) was administered 1 h postinjury, ionized magnesium levels were restored by 2 h postinjury and remained at normal values up to 24 h following brain trauma. Magnesium treatment also significantly reduced posttraumatic neuromotor impairments 1 and 2 weeks after the insult, but failed to attenuate spatial learning deficits. A significant positive and linear correlation could be established between ionized magnesium levels measured 24 h postinjury and neuromotor outcome at 1 and 2 weeks. We conclude that acute ionized magnesium measurement may be a predictor of long-term neurobehavioral outcome following head injury and that delayed administration of magnesium chloride can restore blood magnesium concentration and attenuate neurological motor deficits in brain-injured rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text