Meloxicam and/or Etoricoxib Could Be Administered Safely in Two Equal Doses during an Open Oral Challenge in Patients with Nonsteroidal Anti-Inflammatory Drug Hypersensitivity
| Autor: | Luis Fernando Ramírez Zuluaga, Diana Lucía Silva Espinosa, Diana Martinez, Dolly Vanessa Rojas-Mejía, Carlos Daniel Serrano Reyes |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
medicine.drug_class media_common.quotation_subject Immunology Analgesic Provocation test Placebo Meloxicam Anti-inflammatory Bronchial Provocation Tests Drug Hypersensitivity Etoricoxib Therapeutic index medicine Immunology and Allergy Humans media_common Cyclooxygenase 2 Inhibitors business.industry Drug Substitution Anti-Inflammatory Agents Non-Steroidal General Medicine Anesthesia Drug Therapy Combination business medicine.drug |
| Zdroj: | International archives of allergy and immunology. 182(5) |
| ISSN: | 1423-0097 |
| Popis: | Background: Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) are common. These patients require an effective and safe analgesic alternative. Objective: The aim of the study was to demonstrate the safety of meloxicam and etoricoxib administered by open oral challenge in 2 equal steps in patients with NSAID hypersensitivity. Methods: A cross-sectional, descriptive study of patients with a diagnosis of NSAID hypersensitivity who underwent an oral drug provocation test (DPT) with meloxicam or etoricoxib between January 2011 and August 2017 was conducted. The analysis was performed from a database in BD Clinic. Results: Two hundred and twenty-eight oral provocations were performed with an alternative NSAID (203 with meloxicam and 25 with etoricoxib) in 217 patients with hypersensitivity to NSAIDs. The median age was 38 years. Ninety-eight percent of meloxicam and 100% of etoricoxib DPTs were performed in 2 steps (without previous placebo), and 52% and 64% of meloxicam and etoricoxib DPTs, respectively, were performed with 50% of the therapeutic dose in each step. Tolerance to meloxicam was demonstrated in 192 patients (94.5%) and in 100% of patients receiving etoricoxib. Conclusions: Open oral provocation with meloxicam and etoricoxib carried out in 2 steps without placebo seems to be safe and implies less costs and less time expenditure. Also, it could be performed with 2 equal doses. |
| Databáze: | OpenAIRE |
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