DNA Topoisomerases of Kinetoplastid Parasites: Brief Overview and Recent Perspectives
| Autor: | Sourav Saha, Hemanta K. Majumder, Somenath Roy Chowdhury |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Protein Conformation Overview Recent Zoology Euglenozoa Infections Computational biology Biology Host-Parasite Interactions 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine Protein structure Species Specificity Transcription (biology) parasitic diseases Animals Humans Parasites Kinetoplastida Topoisomerase Topoisomerases fungi General Medicine 030104 developmental biology Targeted drug delivery chemistry Brief 030220 oncology & carcinogenesis biology.protein Protein Multimerization Kinetoplastid DNA Topoisomerases DNA Perspectives |
| Zdroj: | Current Issues in Molecular Biology Volume 31 Issue 1 Pages 45-62 |
| ISSN: | 1467-3037 |
| DOI: | 10.21775/cimb.031.045 |
| Popis: | Topoisomerases are a group of enzymes that resolve DNA topological problems and aid in different DNA transaction processes viz. replication, transcription, recombination, etc. inside cells. These proteins accomplish their feats by steps of DNA strand(s) scission, strand passage or rotation and subsequent rejoining activities. Topoisomerases of kinetoplastid parasites have been extensively studied because of their unusual features. The unique presence of heterodimeric Type IB topoisomerase and prokaryotic 'TopA homologue' Type IA topoisomerase in kinetoplastids still generates immense interest among scientists. Moreover, because of their structural dissimilarity with the host enzymes, topoisomerases of kinetoplastid parasites are attractive targets for chemotherapeutic interventions to kill these deadly parasites. In this review, we summarize historical perspectives and recent advances in kinetoplastid topoisomerase research and how these proteins are exploited for drug targeting. |
| Databáze: | OpenAIRE |
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