Alkaline phosphatase, cytokeratin 7, cytokeratin 8 in the diagnosis of primary lung adenocarcinoma from 148 pleura fluids specimens
| Autor: | Ozhavzali MĂźzeyyen, Temelli Ozlem, TĂźrk Mustafa, Atay Meral, OÄuztĂźzĂźn Serpil, Atay Ziya, Yirtici Umit |
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| Přispěvatelé: | Kırıkkale Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Histology Lung Neoplasms Immunocytochemistry cytokeratine 8 cytokeratine 7 Biology Adenocarcinoma Sensitivity and Specificity Pathology and Forensic Medicine Cytokeratin immunocytochemistry medicine Carcinoma Humans lcsh:QH573-671 Gastrointestinal tract Lung lcsh:Cytology Keratin-8 Keratin-7 body cavity fluids General Medicine respiratory system medicine.disease lung adenocarcinoma Alkaline Phosphatase Immunohistochemistry respiratory tract diseases Pleural Effusion medicine.anatomical_structure Alkaline phosphatase |
| Zdroj: | Folia Histochemica et Cytobiologica, Vol 47, Iss 1, Pp 87-92 (2009) |
| ISSN: | 1897-5631 0239-8508 |
| Popis: | WOS: 000282021000014 PubMed: 19419944 Adenocarcinomas are the most common cause of malignancy in pleura fluids. Usual primary sites include the lung, breast, gastrointestinal tract, and genitourinary tracts. Predicting the site of origin of an adenocarcinoma can be difficult due to overlapping morphologic characteristics. We investigated the use of alkaline phosphatase (AP), Cytokeratin7 (CK7) Cytokeratin8 (CK8) to distinguish adenocarcinomas of lung in 148 body cavity fluid samples. Overall results for primary lung adenocarcinomas, demonstrated CK8 reactivity in 106 (72%) of 148 cases. 95 primary lung carcinoma samples (65%) were positive for CK7. AP was expressed in 81% of primary lung adenocarcinomas. Positive immunoreactivity for AP was characterized by a red, diffusely apical cytoplasmic staining in tumor cells that ocurred singly or in groups. There was a significant difference between AP, CK 7 and CK 8 expressions in primary lung adenocarcinomas (P=0.02; Chi-squared test). The sensitivity of AP, CK8, CK7 as a marker for primary lung adenocarcinomas were 82%, 72%, 64%, respectively. Thus the AP positive staining largely confirmed the cytologic diagnosis of lung adenocarcinoma. |
| Databáze: | OpenAIRE |
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