Global and regional myocardial deformation mechanics of microvascular obstruction in acute myocardial infarction: a three dimensional speckle-tracking imaging study

Autor: Simon Lemoine, Christine Selton-Suty, Pierre-Yves Marie, Lin Zhang, Emilien Micard, Nicolas Sadoul, Damien Mandry, Yves Juillière, Olivier Huttin, Nicolas Girerd, Jérémie Lemarié
Přispěvatelé: Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], Service de Cardiologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service de Réanimation Médicale [CHRU Nancy], Service de Médecine Nucléaire [Nancy], Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
Time Factors
medicine.medical_treatment
Late systolic
Echocardiography
Three-Dimensional
030204 cardiovascular system & hematology
Ventricular Function
Left
030218 nuclear medicine & medical imaging
Strain
Ventricular Dysfunction
Left
0302 clinical medicine
deformation mechanics Ischemia
Myocardial Revascularization
Myocardial infarction
Prospective Studies
Micro vascular obstruction
Cardiac imaging
Observer Variation
Ventricular Remodeling
Transmural infarct
Middle Aged
Biomechanical Phenomena
Treatment Outcome
Echocardiography
Area Under Curve
Cardiology
Female
Cardiology and Cardiovascular Medicine
Adult
medicine.medical_specialty
Area strain
Magnetic Resonance Imaging
Cine
Revascularization
03 medical and health sciences
Predictive Value of Tests
Internal medicine
Coronary Circulation
medicine
Late gadolinium enhancement
Humans
Radiology
Nuclear Medicine and imaging
cardiovascular diseases
Speckle tracking imaging
Aged
business.industry
Microcirculation
Three dimensional
Reproducibility of Results
Stroke Volume
medicine.disease
Myocardial Contraction
ROC Curve
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: International Journal of Cardiovascular Imaging
International Journal of Cardiovascular Imaging, Springer Verlag, 2015, 31 (7), pp.1337-1346. ⟨10.1007/s10554-015-0690-2⟩
ISSN: 1569-5794
1573-0743
DOI: 10.1007/s10554-015-0690-2⟩
Popis: International audience; Microvascular obstruction (MVO) and transmural infarct size are prognostic factors after acute myocardial infarction (AMI). We assessed the value of myocardial deformation patterns using 3D speckle tracking imaging (3DSTI) in detecting myocardial and microvascular damage after AMI. One hundred patients with first ST-segment elevation MI from the REMI Study were prospectively included. Transthoracic echocardiography with 3DSTI and CMR were performed within 72 h after revascularization therapy. Global (3DG) and segmental (3DS) values of LV longitudinal (LS), circumferential and radial area strain were obtained. Late gadolinium enhancement (LGE) and MVO was quantified as transmural (>50%) or non-transmural ( 75%) was 3DSAS [AUC 0.867 (0.849-0.884), 78.0% sensitivity and 81.1% specificity for 3DSAS = -16.1%]. Importantly, 3DSRS and 3DSAS were associated with an increase in diagnostic accuracy of both transmural LGE and MVO over 3DSLS (all increase in AUC > 0.04, all p < 0.01). The newly developed 3DSTI, especially 3DSAS, is a sensitive and reproducible tool to predict and quantify the transmural extent of scar. This new early imaging strategy improve the prediction of MVO while enabling to assess the success of reperfusion and the risk of late systolic remodeling in STEMI.
Databáze: OpenAIRE
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