EM study of the numbers of cortical synapses in the brains of ageing people and people with Alzheimer-type dementia
| Autor: | Gibson Ph |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Aging Pathology medicine.medical_specialty Adolescent Pathology and Forensic Medicine Cellular and Molecular Neuroscience Degenerative disease Alzheimer Disease Cortex (anatomy) medicine Neuropil Humans Dementia Senile plaques Aged Cerebral Cortex business.industry Brain Middle Aged medicine.disease Temporal Lobe Frontal Lobe Microscopy Electron medicine.anatomical_structure Cerebral cortex Ageing Synapses Neurology (clinical) Alzheimer's disease business Mathematics |
| Zdroj: | Acta Neuropathologica. 62:127-133 |
| ISSN: | 1432-0533 0001-6322 |
| DOI: | 10.1007/bf00684929 |
| Popis: | Numbers of synapses were counted in columns of neuropil orientated at right angles to the pia in frontal and temporal regions from postmortem brains. In the frontal region of 28 patients aged 26-90 years there were 1.2 X 10(8) mm3 (SD 0.03 X 10(8], and in the temporal of 18 patients aged 16-90 years there were 1.4 X 10(8) mm3 (SD 0.04 X 10(8]. Regression analysis showed a statistically significant (P less than 0.01) decrease with age for the frontal region but not the temporal. Four patients had been clinically diagnosed as suffering from Alzheimer-type dementia and had neurofibrillary tangles and numerous senile plaques in the cortex. The numbers of synapses in these four patients did not differ from the remaining apparently intellectually normal people. |
| Databáze: | OpenAIRE |
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