Synthesis of heterocyclic analogs of isoflavone and homoisoflavone based on 3-formylchromone

Autor:	S. Ch. Gagieva, Vladislav A. Tuskaev, Eduard T. Oganesyan, Stanislav S. Shatokhin
Rok vydání:	2021
Předmět:	Green chemistry heterocycles chemistry.chemical_compound Chemistry homoisoflavone Reagent Reviews Organic synthesis General Chemistry Combinatorial chemistry isoflavone 3-formylchromone
Zdroj:	Russian Chemical Bulletin
ISSN:	1573-9171 1066-5285
Popis:	The review is focused on recent developments of chemistry of synthetic analogs of natural compounds, isoflavone and homoisoflavone. The possible synthetic strategies to access heterocyclic analogs of these compounds starting from readily available 3-formylchromone and its derivatives (3-cyanochromone, 2-amino-3-formylchromone) and products of its condensation with simplest C- and N-nucleophiles are discussed. The structural features of the reaction products that depend on the nature of the reaction medium, structure of the starting compounds, and reagent ratio are considered. Particular attention is given to the application of the modern strategies of organic synthesis, namely green chemistry approaches, click reactions, domino reactions, etc. Examples of compounds of this group most promising for clinical application due to wide and pronounced pharmacological effects are given.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86194ad12c3df6992f0594488fe0527a https://doi.org/10.1007/s11172-021-3183-6 Zobrazit plný text záznamu Full text from SpringerLink