Glycogenic Hepatopathy in Type 1 Diabetes Mellitus
| Autor: | Kei Moriya, Maiko Nishigori, Kosuke Kaji, Akira Mitoro, Daisuke Kaya, Hitoshi Yoshiji, Tsuyoshi Mashitani, Mitsuteru Kitade, Yukihisa Fujinaga, Shohei Asada, Takuya Kubo, Yasuhiko Sawada, Hideto Kawaratani, Tadashi Namisaki |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases Gastrointestinal Diseases periodic acid-Schiff staining glycogen hepatopathy Case Report Inflammation Gastroenterology Young Adult 03 medical and health sciences glycogenic hepatopathy 0302 clinical medicine Liver Function Tests Fibrosis NAFLD Internal medicine Internal Medicine medicine Humans Periodic Acid-Schiff (PAS) staining 030212 general & internal medicine Type 1 diabetes medicine.diagnostic_test business.industry Liver Diseases Fatty liver nutritional and metabolic diseases General Medicine medicine.disease Staining Diabetes Mellitus Type 1 Editorial Liver biopsy poorly controlled type 1 diabetes mellitus 030211 gastroenterology & hepatology Liver function medicine.symptom business Complication Glycogen type 1 diabetes mellitus Hepatomegaly |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.9490-17 |
| Popis: | Glycogenic hepatopathy (GH) is a rare complication of poorly controlled type 1 diabetes mellitus (T1DM), and is characterized by elevated liver enzymes, hepatomegaly, and glycogen accumulation. We herein present the case of a 23-year-old man with poorly controlled T1DM who had liver dysfunction. Imaging studies showed severe hepatomegaly and fatty liver. The examination of a liver biopsy specimen revealed fatty droplets, ballooning, inflammation, and mild fibrosis. Subsequent periodic acid-Schiff (PAS) staining after diastase digestion confirmed GH. In this case, the improvement of hyperglycemia, not HbA1c, resulted in the improvement of the patient's liver function. This is the first report on the use of continuous glucose monitoring in patients with GH to show that continuous hyperglycemia may worsen GH. |
| Databáze: | OpenAIRE |
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