Clinicopathological correlation of endocan expression and survival in epithelial ovarian cancer
| Autor: | Manal M. El Behery, Mahmoud A. Seksaka, Yehya El Alfy, Moustafa A. Ibrahiem, Hend S Saleh |
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| Rok vydání: | 2012 |
| Předmět: |
Oncology
Adult Male Vascular Endothelial Growth Factor A medicine.medical_specialty Pathology Endothelium Angiogenesis Uterine fibroids medicine.medical_treatment Carcinoma Ovarian Epithelial Internal medicine medicine Humans Neoplasms Glandular and Epithelial Prospective Studies Grading (tumors) Aged Ovarian Neoplasms Hysterectomy Neovascularization Pathologic business.industry Obstetrics and Gynecology Oophorectomy General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry Survival Analysis Neoplasm Proteins medicine.anatomical_structure Multivariate Analysis Egypt Female Proteoglycans Ovarian cancer business |
| Zdroj: | Archives of gynecology and obstetrics. 288(6) |
| ISSN: | 1432-0711 |
| Popis: | Endothelial-cell-specific molecule-1 or endocan is a proteoglycan with tumorigenic activity through both its glycan and protein cores. Endocan mRNA is identified as one of the most significant molecular signatures defining a poor prognosis in lung, breast, kidney, and hepatocellular cancer. To assess the clinical value of endocan expression in ovarian cancer tissues in association with other prognostic factors and its impact on overall survival. Oncology unit of Zagazig University Hospitals, Egypt. Prospective observational cohort. One hundred primary ovarian cancer patients were recruited as study group, another 100 patients undergoing hysterectomy and oophorectomy due to uterine fibroid were the control group. Angiogenesis was determined by immunohistochemical staining, using anti-endocan, and anti vascular endothelial growth factor (VEGF) monoclonal antibodies. Endocan was expressed in endothelium of ovarian cancer tissue specimens in all patients with no expression in endothelium of normal ovarian tissue in the control group. VEGF was also expressed in endothelium of all specimens of ovarian cancer tissue, compared with 70 % expression in normal ovarian tissue specimens in the control group. A significant association was found between endocan-microvessel density (MVD) and tumor histology, tumor size, staging, and grading. No significant association was found between VEGF expression and any of the clinicopathological variables. Overall survival of patients was inversely associated with endocan-MVD (P |
| Databáze: | OpenAIRE |
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