No effects of extremely low frequency magnetic fields found on cytotoxic activities and cytokine production of human peripheral blood mononuclear cells in vitro
| Autor: | Hideki Hirose, Keiichi Ikeda, Hiroki Mizoe, Seiichi Kanao, Fumio Mizuno, Taku Yamakawa, Hiroaki Yoshizawa, Yoshihisa Otaka, Setsu Hasebe, Yasushi Shinmura, Toshio Motomura, Hiroyuki Sumitani, Atsuya Yoshida |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Physiology medicine.medical_treatment Biophysics Lymphokine General Medicine Biology Middle Aged Cytotoxicity Tests Immunologic Peripheral blood mononuclear cell In vitro Killer Cells Natural Immune system Cytokine Electromagnetic Fields Immunology medicine Cytotoxic T cell Cytokines Humans Radiology Nuclear Medicine and imaging Tumor necrosis factor alpha Cytotoxicity Killer Cells Lymphokine-Activated |
| Zdroj: | Bioelectromagnetics. 24(1) |
| ISSN: | 0197-8462 |
| Popis: | Several epidemiologic studies have suggested an association between exposure to extremely low frequency (ELF) magnetic fields (MFs) and cancer in adults and children. A possible target of MFs is the immune system. The effects of the exposure to ELF MFs on the immunological functions of human peripheral blood mononuclear cells (PBMCs) obtained from healthy male volunteers were assessed by measuring the natural killer (NK) and lymphokine activated killer (LAK) activities and the production of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), and interleukin-10 (IL-10). The PBMCs were exposed to three different MF: linearly polarized (vertical), circularly polarized, and elliptically polarized, at 50 and 60 Hz. Magnetic flux densities were set at 500, 100, 20, and 2 μT (rms) for vertical field and at 500 μT (rms) for the rotating fields. Using cytotoxicity assay and enzyme-linked immunosorbent assay (ELISA) for cytokine production, we could not find any effects of ELF MFs on the cytotoxic activities and the cytokines production of human PBMCs. Bioelectromagnetics 24:21–31, 2003. © 2002 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text