Molecularly Imprinted Polymers for α-Tocopherol Delivery

Autor:	Manuela Curcio, Giuseppe Cirillo, Francesca Iemma, Mariarosaria Castiglione, Nevio Picci, Francesco Puoci, Ortensia Ilaria Parisi
Rok vydání:	2008
Předmět:	Materials science Polymers Ethylene glycol dimethacrylate alpha-Tocopherol Pharmaceutical Science Methacrylate Antioxidants Molecular Imprinting chemistry.chemical_compound Drug Delivery Systems Organic chemistry chemistry.chemical_classification Drug Carriers Gastric Juice Intestinal Secretions Molecularly imprinted polymer General Medicine Polymer Controlled release Cross-Linking Reagents Methacrylic acid chemistry Delayed-Action Preparations Methacrylates Drug carrier
Zdroj:	Drug Delivery. 15:253-258
ISSN:	1521-0464 1071-7544
Popis:	Biomedical applications of antioxidants have increased dramatically since the link between human diseases and oxidative stress was established. This paper focuses on alpha -tocopherol and on the possibility of employing molecularly imprinted polymers as a controlled release device for alpha-tocopherol in gastrointestinal simulating fluids. Polymers were synthesized using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as cross-linker. Considerable differences in recognition characteristics between imprinted and non-imprinted polymers, both in organic and in aqueous media, were observed. Imprinted polymers bound much more alpha-tocopherol and showed a controlled/sustained drug release capacity in gastrointestinal simulating fluids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8614f00f9ba654b043cc629db7f6a339 https://doi.org/10.1080/10717540802006724 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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