The association of profilin-1 levels with survival in chronic kidney disease
| Autor: | Ismail Kocyigit, Aydın Güçlü, Mustafa Gezer, Mahmut Ilker Yilmaz, Gokmen Zararsiz, Mutlu Saglam, Ozkan Gungor, Tayfun Eyileten, Ahmet Tas, Ibrahim Aydin, Hilmi Umut Unal, Eray Eroglu, Yusuf Oguz, Murat Karaman |
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| Přispěvatelé: | Kırşehir Ahi Evran Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri, Nefroloji ABD |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Pathology Brachial Artery Clinical Biochemistry Vasodilation profilin-1 macromolecular substances Kaplan-Meier Estimate 030204 cardiovascular system & hematology survival Biochemistry Gastroenterology endothelial dysfunction cardiovascular events 03 medical and health sciences Profilins 0302 clinical medicine Profilin-1 Internal medicine medicine.artery Cause of Death medicine Humans Endothelial dysfunction Stage (cooking) Brachial artery Mortality Renal Insufficiency Chronic Survival analysis Ultrasonography business.industry General Medicine Middle Aged medicine.disease Prognosis 030104 developmental biology Cardiovascular Diseases Cohort Female business chronic kidney disease Kidney disease |
| Zdroj: | European journal of clinical investigation. 47(12) |
| ISSN: | 1365-2362 |
| Popis: | Background Profilin-1 is a ubiquitous, actin-binding protein that plays an important role in the regulation of actin polymerization and cytoskeleton remodeling thus contribute vascular dysfunction.We conducted this study to investigate the association of serum profilin-1 levels with fatal and non-fatal CVE in a cohort of patients with stage 1-5 CKD. Matherials and methods Serum concentrations of profilin-1 levels were determined by enzyme-linked immunosorbent assay. Endothelium-dependent vasodilatation (flow-mediated dilatation (FMD) and endothelium-independent vasodilatation (nitroglycerine mediated dilatation (NMD) of the brachial artery were assessed non-invasively, using high-resolution ultrasound. Results Both fatal and non-fatal CVE was significantly higher in patients with high profilin-1 levels. Kaplan–Meier survival curves showed that patients with profilin-1 below the median value (114 pg/ml) had higher cumulative survival compared with patients who had profilin-1 levels above the median value (log-rank test, P |
| Databáze: | OpenAIRE |
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