Pull-Out Strength of Multifunctional Bioabsorbable Ciprofloxacin-Releasing Polylactide-Polyglycolide 80/20 Tacks
| Autor: | Minna Veiranto, Pertti Törmälä, Kaisa Knuutila, Outi Kaarela, Esa Suokas, Nureddin Ashammakhi, Satu Länsman, Johanna Tiainen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Surface Properties Polyglycolide Biocompatible Materials Bone Nails Diffusion Parietal Bone chemistry.chemical_compound Anti-Infective Agents Polylactic Acid-Polyglycolic Acid Copolymer Ciprofloxacin Cadaver Tensile Strength Absorbable Implants Materials Testing Humans Medicine Lactic Acid Aged Human cadaver Drill business.industry Equipment Design General Medicine Anatomy Middle Aged Surgery medicine.anatomical_structure Otorhinolaryngology chemistry Cranial bone Microscopy Electron Scanning Stress Mechanical business Parietal bone Polyglycolic Acid |
| Zdroj: | Journal of Craniofacial Surgery. 20:58-61 |
| ISSN: | 1049-2275 |
| DOI: | 10.1097/scs.0b013e318190df48 |
| Popis: | In this study, the pull-out forces of recently developed multifunctional bioabsorbable self-reinforced ciprofloxacin-releasing polylactide/polyglycolide (SR-PLGA+AB) 80/20 tacks were compared with plain SR-PLGA 80/20 tacks in human cadaver parietal bones. Pieces of parietal bone (approximately 6 x 20 cm) were harvested from 5 human cadavers (all were male, 29-77 years old). Fifty plain SR-PLGA tacks (diameter, 2.0 mm; length, 6.0 mm) and 50 ciprofloxacin-releasing SR-PLGA tacks of similar dimensions were applied to drill holes using a special tack shooter without tapping the drill holes. The force needed to pull the tacks from human parietal cadaver bones was measured using a universal tensile-testing machine, by tack pull-out speed of 10 mm/min. Means and SDs were calculated and analyzed using Student's t-test (SPSS version 10.0 for Windows). The pull-out forces of the ciprofloxacin-releasing and plain tacks were 147.0 +/- 5.94 and 141.4 +/- 8.97 N respectively (P = 0.14, statistically insignificant difference between the 2 groups). The cause of failure in all cases was barb breakage. Ciprofloxacin-releasing SR-PLGA 80/20 tacks seem to have a similar holding power to cranial bone as plain SR-PLGA (80/20) tacks but have additional advantage of ciprofloxacin release. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|