Cytogenetics of Childhood Acute Myeloid Leukemia
| Autor: | Brenda Gibson, Ian Hann, Chirstine J. Harrison, Siebold S. N. de Graaf, Keith Wheatley, Robert Kerrin Hills, Eva van den Berg, Anthony V. Moorman, Alan Kenneth Burnett, David Grimwade, David Webb |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Cancer Research Myeloid Kaplan-Meier Estimate DE-NOVO PHILADELPHIA-CHROMOSOME CHROMOSOMAL-ABNORMALITIES PEDIATRIC-ONCOLOGY-GROUP Antineoplastic Combined Chemotherapy Protocols PROGNOSTIC-SIGNIFICANCE Odds Ratio Registries ADULT PATIENTS Child In Situ Hybridization Bone Marrow Transplantation ACUTE MYELOGENOUS LEUKEMIA Incidence (epidemiology) Childhood Acute Myeloid Leukemia Myeloid leukemia Prognosis Leukemia Myeloid Acute Leukemia Treatment Outcome medicine.anatomical_structure Oncology Child Preschool Cytogenetic Analysis Female medicine.medical_specialty Adolescent COMPLEX ABERRANT KARYOTYPE Philadelphia chromosome Risk Assessment Disease-Free Survival Fluorescence Translational research [ONCOL 3] Internal medicine Confidence Intervals medicine Humans Genetic Predisposition to Disease NUCLEOPHOSMIN MUTATIONS Survival analysis Probability Proportional Hazards Models Retrospective Studies Chromosome Aberrations Chromosomes Human Pair 12 Chromosomes Human Pair 10 business.industry Infant Retrospective cohort study medicine.disease Survival Analysis United Kingdom INTERNAL TANDEM DUPLICATION Logistic Models Karyotyping Multivariate Analysis Immunology business |
| Zdroj: | Journal of Clinical Oncology, 28, 16, pp. 2674-81 Journal of Clinical Oncology, 28, 2674-81 Journal of Clinical Oncology, 28(16), 2674-2681. AMER SOC CLINICAL ONCOLOGY |
| ISSN: | 1527-7755 0732-183X |
| Popis: | Purpose Karyotype is an independent indicator of prognosis in acute myeloid leukemia (AML) that is widely applied to risk-adapted therapy. Because AML is rare in children, the true prognostic significance of individual chromosomal abnormalities in this age group remains unclear. Patients and Methods This cytogenetic study of 729 childhood patients classified them into 22 subgroups and evaluated their incidence and risk. Results Rearrangements of 11q23 were the most frequent abnormality found in approximately 16% of patients, with 50% of these in infants. The outcome for all patients with 11q23 abnormalities was intermediate; no difference was observed for those with t(9;11)(p21-22;q23). The core binding factor leukemias with the translocations t(8;21)(q22;q22) and inv(16)(p13q22) occurred at incidences of 14% and 7%, respectively, predominantly in older children, and their prognosis was favorable. An adverse outcome was observed in patients with monosomy 7, abnormalities of 5q, and t(6;9)(p23;q34). Abnormalities of 3q and complex karyotypes, in the absence of favorable-risk features, have been associated with an adverse outcome in adults, but the results were not significant in this childhood series. However, the presence of 12p abnormalities predicted a poor outcome. Conclusion Because the spectrum of chromosomal changes and their risk association seem to differ between children and adults with AML, biologic differences are emerging, which will contribute to the redefinition of risk stratification for different age groups in the future. |
| Databáze: | OpenAIRE |
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