Interaction between DRD2 and lead exposure on the cortical thickness of the frontal lobe in youth with attention-deficit/hyperactivity disorder
| Autor: | Chul-Ho Sohn, Jongmin Lee, Jae Won Kim, Jong-Hee Chae, Bongseog Kim, Johanna Inhyang Kim, Min Sup Shin, Hyuk Jin Yun, Bung Nyun Kim, Jaewoo Roh |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Adolescent Audiology behavioral disciplines and activities Developmental psychology 03 medical and health sciences 0302 clinical medicine Dopamine receptor D2 mental disorders medicine Attention deficit hyperactivity disorder Humans Genetic Predisposition to Disease Prefrontal cortex Child Biological Psychiatry Pharmacology Neural correlates of consciousness business.industry Receptors Dopamine D2 Dopaminergic Environmental Exposure Organ Size medicine.disease Magnetic Resonance Imaging Frontal Lobe 030104 developmental biology Cross-Sectional Studies Frontal lobe Lead Attention Deficit Disorder with Hyperactivity Lead exposure Female Gene-Environment Interaction Animal studies business 030217 neurology & neurosurgery |
| Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 82 |
| ISSN: | 1878-4216 |
| Popis: | Background The dopamine receptor D2 receptor (DRD2) gene and lead exposure are both thought to contribute to the pathophysiology of attention-deficit/hyperactivity disorder (ADHD). ADHD is characterized by delay in brain maturation, most prominent in the prefrontal cortex (PFC). The D2 receptor is also mainly located in the PFC, and animal studies show that lead exposure affects the dopaminergic system of the frontal lobe, indicating an overlap in neural correlates of ADHD, DRD2, and lead exposure. We examined the interaction effects of DRD2 rs1800497 and lead exposure on the cortical thickness of the frontal lobe in patients with ADHD. Methods A 1:1 age- and gender-matched sample of 75 participants with ADHD and 75 healthy participants was included in the analysis. The interaction effects of DRD2 and lead exposure on the cortical thickness of 12 regions of interest in the frontal lobe were examined by multivariable linear regression analyses. Results When we investigated the DRD2 × lead effects in the ADHD and HC groups separately, significant DRD2 × lead effects were found in the ADHD group, but not in the healthy control group in multiple ROIs of the frontal lobe. There was a significant negative correlation between the cortical thickness of the right superior frontal gyrus and inattention scores. Conclusions The present findings demonstrated significant interaction effects of DRD2 and lead exposure on the cortical thickness of the frontal lobe in ADHD. Replication studies with larger sample sizes, using a prospective design, are warranted to confirm these findings. |
| Databáze: | OpenAIRE |
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