Plasticity of Metabotropic Glutamate Receptors in Physiological and Pathological Conditions
| Autor: | M.R. L'Episcopo, Daniele F. Condorelli, Maria Vincenza Catania, Eleonora Aronica, Armando A. Genazzani, A. Copani, G. Casabona, Giuseppe Battaglia, Valeria Bruno, F. Nicoletti |
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| Rok vydání: | 1994 |
| Předmět: |
Agonist
medicine.medical_specialty medicine.drug_class Chemistry Metabotropic glutamate receptor 7 Purinergic receptor Metabotropic glutamate receptor 6 Endocrinology Metabotropic receptor Metabotropic glutamate receptor Internal medicine medicine Metabotropic glutamate receptor 2 Long-term depression |
| Zdroj: | The Metabotropic Glutamate Receptors ISBN: 9781617370069 |
| Popis: | Information on native mGluRs has been provided by studies performed in brain slices, synaptoneurosomes, and primary cultures of neurons or astrocytes. In brain slices, mGluRs are either coupled to phosphatidylinositol (PI) turnover (mGluRPI) (Nicoletti et al., 1986a; Schoepp and Johnson, 1988) or negatively linked to adenylyl cyclase activity (mG1uR↓cAMP) (Cartmell et al., 1992; Schoepp et al., 1992; Genazzani et al., 1993). Recently, two independent groups have shown that mGluR agonists activate phospholipase D (Boss and Conn, 1993; Holler et al., 1993), a process that generates large amounts of diacylglycerol as a result of phosphatidylcholine hydrolysis and phosphatidic acid formation. The selective mGluR agonist (1S, 3R)-1-aminocyclopentane-1, 3-dicarboxylic acid (1S, 3R-ACPD) potentiates cAMP responses to agonists of Gs-coupled receptors, and increases basal cAMP formation (Winder and Conn, 1992), by potentiating the response to endogenous adenosine acting at A2 purinergic receptors (Winder and Conn, 1993; Cartmell et a1., 1993; see Chapter 3). |
| Databáze: | OpenAIRE |
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