A Non-Cross-Coupling Approach to Arene-Bridged Macrocycles: Synthesis, Structure, and Direct, Regioselective Functionalization of a Cycloparaphenylene Fragment

Autor:	Bradley L. Merner, John D. Gorden, Nirmal K. Mitra, Rolande Meudom
Rok vydání:	2015
Předmět:	Coupling Fragment (computer graphics) Stereochemistry Chemistry Organic Chemistry Regioselectivity Halogenation Surface modification Physical and Theoretical Chemistry Biochemistry
Zdroj:	Organic Letters. 17:2700-2703
ISSN:	1523-7052 1523-7060
Popis:	A new synthetic strategy that employs a relatively unstrained, 1,4-diketo-bridged macrocycle as a precursor to a strained, 1,4-arene-bridged (bent para-phenylene) macrocycle has been developed. The distorted p-terphenyl nucleus (CPP fragment) of the macrocycle has been characterized by X-ray crystallography, and a direct, regioselective bromination protocol of the macrocyclic system is reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860b293d9f783c0780d98c497f85f07a https://doi.org/10.1021/acs.orglett.5b01102 Zobrazit plný text záznamu