Plant extracts inhibit ADP-induced platelet activation in humans: their potential therapeutic role as ADP antagonists
| Autor: | Indera Anita Jagroop |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
P2Y receptor
Review Article Pharmacology Cellular and Molecular Neuroscience chemistry.chemical_compound Cangrelor P2Y12 medicine Humans Platelet Platelet activation Ticlopidine Molecular Biology Plant Extracts business.industry Purinergic receptor Cell Biology Platelet Activation Adenosine Diphosphate Adenosine diphosphate chemistry Biochemistry Purinergic P2Y Receptor Antagonists business Platelet Aggregation Inhibitors Phytotherapy medicine.drug |
| Zdroj: | Purinergic Signalling. 10:233-239 |
| ISSN: | 1573-9546 1573-9538 |
| DOI: | 10.1007/s11302-013-9393-0 |
| Popis: | Adenosine diphosphate (ADP) plays a pivotal role in platelet activation. Platelet hyperactivity is associated with vascular disease and also has a key role in haemostasis and thrombosis. ADP activates platelets through three purinoceptor subtypes, the G(q)-coupled P2Y(1) receptor, G(i)-coupled P2Y(12) receptor and P2X(1) ligand-gated cation channel. Platelet ADP purinergic receptors are therefore suitable targets for antiplatelet drugs. Thienopyridines such as clopidogrel and ticlopidine, as well as other ADP receptor antagonists like prasugrel, ticagrelor, cangrelor and elinogrel have demonstrated clinical benefits via the inhibition of the selective purinergic ADP receptor, P2Y(12). However, they still have limitations in their mode of action and efficacy, like increased risk of bleeding. Thus, the ongoing pursuit to develop newer and more effective antiplatelet agents continues. There is a growing interest in the purinergic antiplatelet properties exhibited by plant extracts. This article considers the following: pomolic acid isolated from Licania pittieri, brazilin isolated from the heartwood of Caesalpinia sappan L, phylligenin isolated from the twigs of Muraltia vulpina, bark oil of Gonystylus velutinus, seed and bark extracts from Aesculus hippocastanum L. and red wine phenolics and catechins isolated from green tea. Moreover, the method used to investigate platelet purinergic receptors should be considered, since using a more sensitive, high-resolution platelet sizer can sometimes detect platelet variations when the light transmission method was not able to do so. The exact mechanisms by which these plant extracts work need further investigation. They all however inhibit ADP-induced activation in human platelets. This could explain, at least in part, the protective effect of plant extracts as antiplatelet agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink