Potential therapeutic target genes for systemic lupus erythematosus: a bioinformatics analysis
| Autor: | Liang Liu, Huihui Bao, Long-long Hu, Junpei Li, Jing-an Rao, Xiaoshu Cheng, Lingjuan Zhu, Yun Yu, Rong-Wei Zhang, Qian Liang, Lingling Yu |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
differentially expressed genes Bioinformatics analysis Bioengineering CCL2 MMP9 Applied Microbiology and Biotechnology 03 medical and health sciences Systemic lupus erythematosus 0302 clinical medicine immune system diseases Databases Genetic medicine Humans Lupus Erythematosus Systemic Protein Interaction Maps skin and connective tissue diseases Gene Autoimmune disease business.industry Computational Biology biomarkers Tissue-Specific Gene Expression bioinformatics General Medicine medicine.disease 030104 developmental biology Differentially expressed genes Organ Specificity Immunology tissue-specific gene expression Etiology Transcriptome business TP248.13-248.65 Research Article Research Paper 030215 immunology Biotechnology |
| Zdroj: | Bioengineered article-version (VoR) Version of Record Bioengineered, Vol 12, Iss 1, Pp 2810-2819 (2021) |
| ISSN: | 2165-5987 2165-5979 |
| DOI: | 10.1080/21655979.2021.1939637 |
| Popis: | Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organs. However, the underlying etiology and mechanisms remain unclear. This study was performed to identify potential therapeutic targets for SLE using bioinformatics methods. First, 584 differentially expressed genes were identified based on the GSE61635 dataset. Tissue-specific analyses, enrichment analyses, and Protein–Protein interaction network were successively conducted. Furthermore, ELISA was performed to confirm the expression levels of key genes in the control and SLE blood samples. The findings revealed that tissue-specific expression of markers of the hematological system (25.5%, 28/110) varied significantly. CCL2, MMP9, and RSAD2 expression was markedly increased in the SLE samples compared with controls. In conclusion, the identified key genes (CCL2, MMP9, and RSAD2) may act as possible therapeutic targets for the treatment of SLE. GRAPHICAL ABSTRACT |
| Databáze: | OpenAIRE |
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