Multiple endocrine neoplasia type 1 associated with spinal ependymoma
| Autor: | Kazuhiko Fujisawa, Isao Uchimura, Fujio Numano, Yasushi Kobayashi, Mitsuo Endo, Hisayoshi Kato, Atsuhisa Tamura, Masaharu Morohoshi, Chikao Nagashima, Narihide Goseki |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Ependymoma
Male Pathology medicine.medical_specialty Central nervous system disease Pituitary adenoma Pancreatic tumor Internal Medicine medicine Multiple Endocrine Neoplasia Type 1 Endocrine system Humans Multiple endocrine neoplasia Insulinoma Chromosome Aberrations Hyperparathyroidism Spinal Neoplasms business.industry Chromosomes Human Pair 11 General Medicine Middle Aged medicine.disease Pedigree Female business |
| Zdroj: | Internal medicine (Tokyo, Japan). 35(4) |
| ISSN: | 0918-2918 |
| Popis: | A 51-year-old man was hospitalized with a gait disturbance and hypoesthesia below the level of his chest. These symptoms were due to a spinal tumor which was surgically resected and identified as an ependymoma. Additionally, the patient had hypercalcemia and a family history of insulinoma. An endocrine evaluation revealed parathyroid hyperplasia and a pancreatic islet cell tumor. Magnetic resonance imaging disclosed a pituitary microadenoma. He was diagnosed with spinal ependymoma and multiple endocrine neoplasia type 1 (MEN 1). A review of the literature revealed that chromosome 11q13 abnormalities have been reported in both ependymoma and MEN 1. We discuss the pathogenesis of these diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|