Infundibuloneurohypophysitis associated with autoimmune thrombocytopenia and chiasmal syndrome: a case report
| Autor: | Lucilla Gargano, Alessandro Caporlingua, Miriam Cellini, Luca D'Angelo, Patrizia Gargiulo, Felice Giangaspero, Maria Pia Tropeano, Valeria Mercuri, Vigliotta Massimo, Ludovica De Vincentiis, Antonio Santoro |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty endocrine system diseases Hypophysitis medicine.medical_treatment Vision Disorders Optic chiasm Hypopituitarism Lesion 03 medical and health sciences 0302 clinical medicine Humans Medicine Autoimmune Hypophysitis 030212 general & internal medicine Pituitary stalk Transsphenoidal surgery Purpura Thrombocytopenic Idiopathic business.industry Chiasmal syndrome General Medicine medicine.disease chiasmal syndrome hypophysitis pituitary transsphenoidal surgery medicine.anatomical_structure Optic Chiasm Diabetes insipidus Neurology (clinical) Radiology medicine.symptom business Diabetes Insipidus 030217 neurology & neurosurgery |
| Zdroj: | Acta Neurologica Belgica. 119:337-342 |
| ISSN: | 2240-2993 0300-9009 |
| DOI: | 10.1007/s13760-018-1007-8 |
| Popis: | Lymphocytic hypophysitis is an uncommon autoimmune disease. It may involve the adenohypophysis, neurohypophysis and pituitary stalk. It is most often encountered in pregnant women. Its diagnosis and management pose a significant challenge, as its clinical manifestation and appearance in imaging studies are difficult to distinguish from more common lesion of the sellar region (e.g., pituitary adenomas). We present the case of a 42-year-old man who presented with a chiasmatic syndrome, diabetes insipidus and hypopituitarism. Brain MRI documented a sellar lesion with suprasellar extension and optic chiasm dislocation. He underwent an endoscopic endonasal transsphenoidal resection of the mass. Histopathological examination revealed a lymphocytic hypophysitis. Visual symptoms improved dramatically postoperatively with permanent diabetes insipidus and panhypopituitarism. We discuss the indication for surgical resection in patients with inflammatory lesions extending to the suprasellar region associated with visual impairment. |
| Databáze: | OpenAIRE |
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