Immunohistochemical Expression of Vascular Endothelial Growth Factor as a Prognostic Marker for Canine Mast Cell Tumors
Autor: | Eric Vieira Januario, Samanta Rios Melo, Júlia Maria Matera, Erika De Brito Marco Zanuto, Bruno Cogliati, Bruna de Castro Miranda, Thais Rodrigues Macedo |
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Rok vydání: | 2021 |
Předmět: |
Vascular Endothelial Growth Factor A
Prognostic factor Pathology medicine.medical_specialty 040301 veterinary sciences VEGF receptors Mast-Cell Sarcoma Vegf expression Mast cell tumors 0403 veterinary science chemistry.chemical_compound Dogs FATORES DE CRESCIMENTO Histologic grade Biomarkers Tumor Animals Medicine Dog Diseases Mast Cells Small Animals biology Vascular Endothelial Growth Factors business.industry 0402 animal and dairy science 04 agricultural and veterinary sciences Prognosis Immunohistochemistry 040201 dairy & animal science Staining Vascular endothelial growth factor chemistry biology.protein business Biomarkers |
Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
ISSN: | 1938-9736 |
Popis: | Strong to moderate vascular endothelial growth factor (VEGF) expression may be a negative prognostic factor in canine mast cell tumors (MCTs). This study set out to determine the prognostic value of combined analysis of VEGF-A immunoreactivity, clinical presentation, patient staging, and tumor histologic grade in canine MCTs. In this study, intense VEGF staining was significantly associated with decreased survival (P = .025). Immunohistochemical expression of VEGF is not routinely employed as a prognostic factor in canine MCT workup. However, results of this study support the inclusion of this marker in the MCT prognostic panel. Investigation of VEGF expression may assist in the development of anti-VEGF drugs. |
Databáze: | OpenAIRE |
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