A cooperative interaction between LPHN3 and 11q doubles the risk for ADHD

Autor: Hakon Hakonarson, Tobias J. Renner, Andres Arbelaez, Ana C. Londoño, Mauricio Arcos-Burgos, Jobst Meyer, Juan Davis Palacio, David Pineda, Susanne Walitza, Francisco X. Castellanos, Christiane Seitz, Erich Roessler, Klaus-Peter Lesch, Haukur Palmason, Mahim Jain, James M. Swanson, Jasmin Romanos, Christian Jacob, Marcel Romanos, Joan Z. Balog, Francisco Lopera, Christine M. Freitag, Maria T. Acosta, Joan E. Bailey-Wilson, Louis Guillermo Palacio, U. Hemminger, Josephine Elia, Jorge I. Vélez, Maximilian Muenke, Andreas Warnke
Přispěvatelé: University of Zurich, Arcos-Burgos, Mauricio
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Magnetic Resonance Spectroscopy
LPHN3
Genetic Linkage
Glutamine
2804 Cellular and Molecular Neuroscience
Medical and Health Sciences
Receptors
G-Protein-Coupled
Choline
2738 Psychiatry and Mental Health
Receptors
genetic interaction
Pair 11
Genetics
ddc:616
Psychiatry
Brain
Single Nucleotide
Biological Sciences
10058 Department of Child and Adolescent Psychiatry
Psychiatry and Mental health
Peptide
Original Article
Protons
Genetic isolate
Human
Receptors
Peptide
Single-nucleotide polymorphism
610 Medicine & health
Biology
Polymorphism
Single Nucleotide
Genetic determinism
Chromosomes
Cellular and Molecular Neuroscience
G-Protein-Coupled
Gene interaction
Genetic linkage
medicine
1312 Molecular Biology
Attention deficit hyperactivity disorder
Humans
ADHD
Genetic Predisposition to Disease
Genetic variability
Polymorphism
Molecular Biology
NCAM1
Aspartic Acid
Chromosomes
Human
Pair 11
Psychology and Cognitive Sciences
medicine.disease
Attention Deficit Disorder with Hyperactivity
Case-Control Studies
Methylphenidate
DRD2
Pharmacogenetics
Inositol
Zdroj: Molecular psychiatry, vol 17, iss 7
Molecular Psychiatry
Popis: In previous studies of a genetic isolate, we identified significant linkage of attention deficit hyperactivity disorder (ADHD) to 4q, 5q, 8q, 11q and 17p. The existence of unique large size families linked to multiple regions, and the fact that these families came from an isolated population, we hypothesized that two-locus interaction contributions to ADHD were plausible. Several analytical models converged to show significant interaction between 4q and 11q (P
Databáze: OpenAIRE
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